Does the Anti-Migraine Drug Rizatriptan Affect Early Neural Tube Development in Chick Embryos?

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dc.contributor.authorSayin, M
dc.contributor.authorGurgen, GS
dc.contributor.authorSayin, SS
dc.contributor.authorGuvenc, G
dc.contributor.authorYuceer, N
dc.date.accessioned2024-07-18T12:03:08Z
dc.date.available2024-07-18T12:03:08Z
dc.description.abstractAIM: To investigate the impact of rizatriptan on neural tube development using early chick embryos as a model organism. MATERIAL and METHODS: A total of 36 pathogen-free Leghorn chicken eggs were selected and categorized in three groups: sham, therapeutic, and supra-therapeutic. After 24 hours, the eggs were opened and injected with sterile drugs, and then reclosed using plastic tape. After a period of 72 hours, the eggs were opened and assessed using the Hamburger-Hamilton chick embryology classification method. TUNEL staining was used to identify apoptosis, and hematoxylin-eosin staining was used to investigate neural tube closure. RESULTS: Treatment with rizatriptan significantly slowed down neural tube development. The supra-therapeutic group showed neural tube closure defects. CONCLUSION: Rizatriptan had a negative effect on neural tube closure. Further research is needed to identify a safe and effective drug for treating migraines during pregnancy.
dc.identifier.issn1019-5149
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/8920
dc.language.isoEnglish
dc.publisherTURKISH NEUROSURGICAL SOC
dc.subjectHYPERTENSIVE DISORDERS
dc.subjectMIGRAINE
dc.subjectPREGNANCY
dc.subjectTRIPTANS
dc.subjectWOMEN
dc.subjectRISK
dc.titleDoes the Anti-Migraine Drug Rizatriptan Affect Early Neural Tube Development in Chick Embryos?
dc.typeArticle

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