Sonic hedgehog, TBX18, and TSHZ3 proteins involved in pyeloureteral motility development are overexpressed in ureteropelvic junction obstruction: An immunohistochemical, histopathological, and clinical comparative study

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dc.contributor.authorYilmaz O.
dc.contributor.authorNese N.
dc.contributor.authorDalgic M.
dc.contributor.authorKesici G.P.
dc.contributor.authorGenc A.
dc.contributor.authorTaneli C.
dc.contributor.authorGunsar C.
dc.contributor.authorSencan A.
dc.contributor.authorCayirli H.
dc.contributor.authorIsisag A.
dc.date.accessioned2024-07-22T08:11:54Z
dc.date.available2024-07-22T08:11:54Z
dc.date.issued2016
dc.description.abstractObjectives: To compare pathological samples obtained from cases that underwent surgery for ureteropelvic junction (UPJ) obstruction with samples obtained during autopsies of subjects. Methods: Retrospectively, 42 patients who had undergone surgery due to UPJ obstruction (group 1) were included in the study. Histopathological and immunohistochemical features for sonic hedgehog (SHH), TBX18, and TSHZ3 of UPJ were evaluated and findings were compared with 20 autopsy cases (group 2). Original Articles Results: In group 1, the scores were statistically significantly higher in terms of cytoplasmic SHH, nuclear TBX18, cytoplasmic and nuclear TSHZ3 staining. Statistically, no correlation was found between age and the staining scores belonging to these 3 antibodies in group 1 and group 2. Intense inflammation was found to be related with nuclear staining for TBX18. Conclusion: Gene product expressions of SHH, TBX18 and TSHZ3 are statistically higher in patients with UPJ obstruction, when compared with control group. The explanation may be the reactivation of the processes, which had shown their effects in the embryological period, due to the chronic inflammation and long-term micro-trauma created by the disease. © 2016, Saudi Arabian Armed Forces Hospital. All rights reserved.
dc.identifier.DOI-ID10.15537/smj.2016.7.14789
dc.identifier.issn03795284
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15829
dc.language.isoEnglish
dc.publisherSaudi Arabian Armed Forces Hospital
dc.rightsAll Open Access; Gold Open Access; Green Open Access
dc.subjectHedgehog Proteins
dc.subjectHomeodomain Proteins
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectT-Box Domain Proteins
dc.subjectUreteral Obstruction
dc.subjectsonic hedgehog protein
dc.subjectT box transcription factor
dc.subjectT box transcription factor 18
dc.subjecttranscription factor ZEB1
dc.subjectunclassified drug
dc.subjecthomeodomain protein
dc.subjectSHH protein, human
dc.subjectsonic hedgehog protein
dc.subjectT box transcription factor
dc.subjectTbx18 protein, human
dc.subjectTSHZ3 protein, human
dc.subjectadolescent
dc.subjectArticle
dc.subjectautopsy
dc.subjectchild
dc.subjectclinical article
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectechography
dc.subjectfemale
dc.subjectgene overexpression
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman tissue
dc.subjecthydronephrosis
dc.subjecthypertrophy
dc.subjectimmunohistochemistry
dc.subjectinflammation
dc.subjectmale
dc.subjectpreschool child
dc.subjectretrospective study
dc.subjectstone formation
dc.subjectureteropelvic junction obstruction
dc.subjectmetabolism
dc.subjectureter obstruction
dc.titleSonic hedgehog, TBX18, and TSHZ3 proteins involved in pyeloureteral motility development are overexpressed in ureteropelvic junction obstruction: An immunohistochemical, histopathological, and clinical comparative study
dc.typeArticle

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