Neuroprotective effects of oleocanthal, a compound in virgin olive oil, in a rat model of traumatic brain injury

Simple item page
dc.contributor.authorMete M.
dc.contributor.authorAydemir I.
dc.contributor.authorUnsal U.U.
dc.contributor.authorCollu F.
dc.contributor.authorVatandas G.
dc.contributor.authorGurcu B.
dc.contributor.authorDuransoy Y.K.
dc.contributor.authorTaneli F.
dc.contributor.authorTuglu M.I.
dc.contributor.authorSelcuki M.
dc.date.accessioned2025-04-10T11:08:11Z
dc.date.available2025-04-10T11:08:11Z
dc.date.issued2018
dc.description.abstractAIM: To evaluate the neuroprotective effects of deocanthal OC in a rat model of traumatic brain injury (TBI). MATERIAL and METHODS: Twenty-six adult male, Wistar albino rats were used. The rats were divided into 4 groups. Group 1 was the sham group (n = 5). Group 2 was the trauma group (n = 5) where rats were treated with 10 mg/kg saline intraperitoneally (IP) twice a day. Groups 3 and 4, rats were treated with 10 (group 3, n = 8) or 30 (group 4, n = 8) mg/kg OC IP twice a day. For each group, brain samples were collected 72 hours after injury. Brain samples and blood were evaluated with histopathological and biochemical methods. RESULTS: Histopathological evaluation revealed a significant difference between Group 2 and Group 4. Biochemical findings demonstrated that the oxidative stress index was highest in Group 2 and lowest in Group 4. CONCLUSION: OC has a protective effect on neural cells after TBI. This effect is achieved by reducing oxidative stress and apoptosis. © 2018 Turkish Neurosurgical Society.
dc.identifier.DOI-ID10.5137/1019-5149.JTN.21417-17.2
dc.identifier.urihttp://hdl.handle.net/20.500.14701/47858
dc.publisherTurkish Neurosurgical Society
dc.titleNeuroprotective effects of oleocanthal, a compound in virgin olive oil, in a rat model of traumatic brain injury
dc.typeArticle

Files

Collections

Scopus Koleksiyonu