Histological and Biochemical Investigation of the Effects of Low Intensity Pulsed Ultrasound on Orthodontic Tooth Movement

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dc.contributor.authorCesur, MG
dc.contributor.authorOnal, T
dc.contributor.authorBilgin, MD
dc.contributor.authorSirin, FB
dc.contributor.authorInan, S
dc.contributor.authorKoken, EC
dc.contributor.authorAlkan, A
dc.contributor.authorCesur, G
dc.date.accessioned2024-07-18T12:06:12Z
dc.date.available2024-07-18T12:06:12Z
dc.description.abstractObjective: The goal of our study is to assess the effects of low intensity pulsed ultrasound on orthodontic tooth movement in rats. Methods: For this study, 40 adult male Wistar albino rats (12-weeks old age) were used from the Animal Laboratory at Adnan Menderes University. Rats were divided into four groups each of ten. Group 1 was the untreated as a control. In group 2, an orthodontic spring was used to move teeth. For groups 3 and 4, orthodontic treatment was combined with low intensity pulsed ultrasound at 16 J/cm2 or 48 J/cm2 for 14 days, respectively. Tooth movement was measured at the last day of treatment. Serum bone alkaline phosphatase (BALP) and C-telopeptide type I collagen (CTX-I) levels were analyzed biochemically. The number of osteoclasts, osteoblasts and inflammatory cells, capillary density and new bone formation was determined histologically. Receptor activator of nuclear factor-kappa B ligand (RANKL), osteoprotegerin (OPG), vascular endothelial growth factor (VEGF) and transforming growth factor-beta (TGF-beta) were assessed using immunohistochemical staining. Results: BALP and CTX-I levels in group 4 were significantly higher compared to control (p<0.05). Tooth movement and the number of osteoclasts, inflammatory cells and capillary density in group 4 were significantly greater than group 2 (p<0.05). The intensity levels of RANKL and OPG in group 4 were significantly greater than group 2 (p<0.05). Conclusions: Ultrasound is a noninvasive application and promising therapy for accelerating bone remodelling during orthodontic tooth movement.
dc.identifier.issn1309-3878
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/10258
dc.language.isoEnglish
dc.publisherDUZCE UNIV, FAC MEDICINE
dc.subjectLEVEL LASER THERAPY
dc.subjectBONE METABOLISM
dc.subjectRESORPTION
dc.subjectINJECTION
dc.subjectTISSUE
dc.subjectROOT
dc.titleHistological and Biochemical Investigation of the Effects of Low Intensity Pulsed Ultrasound on Orthodontic Tooth Movement
dc.typeArticle

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