Comparison of Nephron-protective Effects of Enalapril and GLP Analogues (Exenatide) in Diabetic Nephropathy

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dc.contributor.authorÇavusoglu, T
dc.contributor.authorErbas, O
dc.contributor.authorKaradeniz, T
dc.contributor.authorAkdemir, O
dc.contributor.authorAcikgoz, E
dc.contributor.authorKaradeniz, M
dc.contributor.authorTuglu, MI
dc.contributor.authorAtes, U
dc.date.accessioned2024-07-18T12:06:02Z
dc.date.available2024-07-18T12:06:02Z
dc.description.abstractBackground: One of the major concerns is a nephropathy in diabetes, which applies many different kinds of medicines. However, required level of the treatment of renal disease has not been achieved. Aim: To investigate and compare the effect of the enalapril and the exenatide on diabetic nephropathy in rats developed diabetes by streptozosin. Material and Methods: 32 male Sprague Dawley rats were divided into 4 groups: (1) Control, (2) Diabetic (DM), (3) DM + Enalapril, and (4) DM + exenatide groups. Then, the animals were euthanized and their blood samples were collected by cardiac puncture for blood glucose; blood urea nitrogen (BUN), creatinin, and nephrectomy were performed for histopathologic examination, and urine samples were taken on stick for proteinuria. Results: Administration of the enalapril or the exenatide in diabetic rats resulted in a significant reduction both fibronectin, induced nitric oxide synthase (i-NOS) expression in glomerular area and urine protein levels. It was shown that both of enalapril and exenatide protected the renal glomerulus more than diabetic group in the nephropathy histopathologically. Conclusion: The beneficial effects of enalapril and exenatide which reduces fibronectin, i-NOS expression and urine protein levels or increases recovery of glomerules, might be used for preventing the harmful effects of diabetic nephropathy.
dc.identifier.issn0947-7349
dc.identifier.other1439-3646
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/10149
dc.language.isoEnglish
dc.publisherJOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
dc.subjectOXIDATIVE STRESS
dc.subjectDPP-4 INHIBITION
dc.subjectMESANGIAL CELLS
dc.subjectMICROALBUMINURIA
dc.subjectEXPRESSION
dc.subjectRECEPTOR
dc.subjectCOMPLICATIONS
dc.subjectHYPERTENSION
dc.subjectALBUMINURIA
dc.subjectPROGRESSION
dc.titleComparison of Nephron-protective Effects of Enalapril and GLP Analogues (Exenatide) in Diabetic Nephropathy
dc.typeArticle

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