Acute responses of strength-related gene expressions to maximum strength and force sense acuity

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dc.contributor.authorAltun M.
dc.contributor.authorBalcan E.
dc.contributor.authorBatir S.
dc.contributor.authorGökmen M.H.
dc.contributor.authorÖzgüneş Ş.
dc.contributor.authorÖztel Z.
dc.date.accessioned2024-07-22T08:01:49Z
dc.date.available2024-07-22T08:01:49Z
dc.date.issued2024
dc.description.abstractBackground/aim: Although high muscle strength worsens the sense of force, it is unknown whether there is a relationship between this deterioration and the underlying molecular mechanisms. This study examined the relationship between decreased force sense (FS) acuity and strength-related gene expressions. Materials and methods: Maximal voluntary isometric contraction (MVIC) and FS (50% MVIC) tests were performed on the knee joints of twenty-two subjects. The expression analyses were evaluated by qRT-PCR in blood samples taken before, after MVIC, after 50% MVIC, and 15 min after the test. Results: MVIC and FS error values were significantly correlated with each other (r = .659, p = .001). The qRT-PCR analyses demonstrated that the expressed mRNAs of the interleukin 6 (IL-6), alpha-actinin 3 (ACTN3), angiotensin-converting enzyme (ACE), brain-derived neurotrophic factor (BDNF), and ciliary neurotrophic factor receptor (CNTFR) genes dramatically increased until 50% MVIC and subsequently decreased 15 min after the exercise (p <.05). The muscle-specific creatine kinase (CKMM), myosin light chain kinase (MLCK), and G-protein β3 subunit (GNB3) genes reached their peak expression levels 30 min after MVIC (p < .05). ACE and ACTN3 gene expression increased significantly in parallel with the increased FS error (p <.05). These gene expression fluctuations observed at 50% MVIC and after the rest could be related to changes in cellular metabolism leading to fatigue. Conclusion: The time points of gene expression levels during exercise need to be considered. The force acuity of those whose maximal force develops too much may deteriorate. © TÜBİTAK.
dc.identifier.DOI-ID10.55730/1300-0144.5775
dc.identifier.issn13000144
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11583
dc.language.isoEnglish
dc.publisherTurkiye Klinikleri
dc.rightsAll Open Access; Hybrid Gold Open Access
dc.subjectActinin
dc.subjectAdult
dc.subjectBrain-Derived Neurotrophic Factor
dc.subjectFemale
dc.subjectGene Expression
dc.subjectHumans
dc.subjectInterleukin-6
dc.subjectIsometric Contraction
dc.subjectKnee Joint
dc.subjectMale
dc.subjectMuscle Strength
dc.subjectMuscle, Skeletal
dc.subjectPeptidyl-Dipeptidase A
dc.subjectYoung Adult
dc.subjectalpha actinin 3
dc.subjectbrain derived neurotrophic factor
dc.subjectciliary neurotrophic factor receptor
dc.subjectcreatine kinase MM
dc.subjectdipeptidyl carboxypeptidase
dc.subjectguanine nucleotide binding protein beta subunit
dc.subjectinterleukin 6
dc.subjectmyosin light chain kinase
dc.subjectactinin
dc.subjectinterleukin 6
dc.subjectadult
dc.subjectArticle
dc.subjectblood sampling
dc.subjectbody composition
dc.subjectcell metabolism
dc.subjectexercise
dc.subjectfatigue
dc.subjectfemale
dc.subjectforce
dc.subjectforce sense acuity
dc.subjectgene expression
dc.subjectgene expression level
dc.subjectgenetic analysis
dc.subjecthuman
dc.subjectknee joint
dc.subjectknee ligament
dc.subjectmale
dc.subjectmuscle isometric contraction
dc.subjectmuscle strength
dc.subjectphysical activity
dc.subjectreal time polymerase chain reaction
dc.subjectRNA extraction
dc.subjectstrength related gene expression
dc.subjectvisual feedback
dc.subjectyoung adult
dc.subjectgene expression
dc.subjectgenetics
dc.subjectmetabolism
dc.subjectmuscle isometric contraction
dc.subjectphysiology
dc.subjectskeletal muscle
dc.titleAcute responses of strength-related gene expressions to maximum strength and force sense acuity
dc.typeArticle

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