Gastric emptying of solids and its relationship with microalbuminuria in children and adolescents with type 1 diabetes mellitus
| dc.contributor.author | Ersoy, B | |
| dc.contributor.author | Sayit, E | |
| dc.contributor.author | Can, S | |
| dc.contributor.author | Urk, V | |
| dc.contributor.author | Batok, D | |
| dc.contributor.author | Polat, M | |
| dc.date.accessioned | 2024-07-18T11:52:11Z | |
| dc.date.available | 2024-07-18T11:52:11Z | |
| dc.description.abstract | Background: The aims of the present study were to determine the frequency of delayed gastric emptying in children and adolescents with type 1 diabetes mellitus (T1DM) and to investigate the relationship between gastric emptying rate and other contributing factors (e. g. serum HbA1c, duration of diabetes and microalbuminuria) in these patients. Methods: This was a clinical trial evaluating the rate of gastric emptying of solid meals in 33 children and adolescents with T1DM and in 26 healthy peers using a radionuclide method. Three consecutive overnight urine collections were used to calculate the albumin excretion rate. Results: There was no significant difference in the gastric half-emptying time (GE t 1/2) between patients and controls (151.7 +/- 154.5 vs 109.8 +/- 60.5 min, respectively; P = 0.885) or the frequency of delayed gastric emptying (36.4% vs 30.8%, respectively; P = 0.433). There was a moderately positive correlation between GE t1/2 and the duration of diabetes (r = 0.380; P = 0.029). There was no correlation between GE t1/2 and microalbumin levels in T1DM patients. In these patients, the body mass index standard deviation scores were significantly lower than in patients with normal gastric emptying (-0.13 +/- 0.87 vs 0.7 +/- 1.23, respectively; P = 0.044). Conclusion: Progression of delayed gastric emptying is more likely to be related to a longer duration of diabetes than glycemic control in children and adolescents with T1DM. Patients with delayed gastric emptying are thinner compared with patients with a normal rate of gastric emptying; they may also be asymptomatic. | |
| dc.identifier.issn | 1753-0393 | |
| dc.identifier.uri | http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/5441 | |
| dc.language.iso | English | |
| dc.publisher | WILEY-BLACKWELL | |
| dc.subject | ACID BREATH TEST | |
| dc.subject | CLINICAL-SIGNIFICANCE | |
| dc.subject | AUTONOMIC NEUROPATHY | |
| dc.title | Gastric emptying of solids and its relationship with microalbuminuria in children and adolescents with type 1 diabetes mellitus | |
| dc.type | Article |