Changes of plasma magnesium concentrations in peroperative magnesium administration for analgesia; [Peroperatif analjezi amaçli magnezyum uygulamasinda plazma magnezyum düzeyi degişiklikleri]
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2001
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Abstract
We evaluated the effect of peroperative magnesium replacement on analgesic consumption and changes of plasma magnesium (Mg) concentrations peroperatively. We administered % 0.9 NaCl (Group K, n=20) and MgSO4 (Group M, n=20) bolus and infusion peroperative and untill the end of the postoperative 6th hour in patients undergoing total hysterectomy. Fentanyl 3 μg/kg, propofol 2 mg/kg and vecuronium 0.1 mg/kg had been given in anesthesia induction and continued with % 60 N2O+O2 and 1 % sevoflurane after tracheal intubation into the both groups. Fentanyl 2 μg/kg had been added when heart rate (HR) and mean arterial pressure (MAP) were 15-20 % greater than basal values in all patients. Plasma Mg concentration, MAP and HR were recorded preoperatively, after induction and incision, on postoperative 30. min., 3-6th hours. In addition VAS and sedation scores were recorded postoperatively. Patient controlled analgesia with fentanyl was used for postoperative analgesia. Total fentanyl dose, demand and delivery were recorded. Intraoperative fentanyl consumption was decreased by 40 % in Group M. Postoperative fentanyl consumption was not different between two groups. VAS scores decreased on the 3th and 6th hours in comparison to 30th min postoperatively in Group M. Blood magnesium concentrations were decreased after preoperative period in Group K, and all recordings were higher than preoperative values in Group M. In conclusion, we believed that blood magnesium concentration decreases peroperatively in total hysterectomies, and that the doses we choose were safe despite increased plasma Mg concentration.
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fentanyl , magnesium , magnesium sulfate , nitrous oxide , oxygen , propofol , sevoflurane , vecuronium , abdominal hysterectomy , adult , aged , anesthesia induction , article , bolus injection , clinical article , clinical trial , controlled clinical trial , controlled study , disease course , drug infusion , drug use , female , heart rate , human , hypertension , inhalation anesthesia , magnesium blood level , mean arterial pressure , pain assessment , patient controlled analgesia , peroperative care , postoperative pain , postoperative period , sedation , skin incision , supplementation , tachycardia , visual analog scale