The Effect of Cynara cornigera L. in HepG2 Hepatocellular Carcinoma Cells

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dc.contributor.authorSanlidag, E
dc.contributor.authorBecer, E
dc.contributor.authorÇalis, I
dc.contributor.authorBaser, KHC
dc.contributor.authorHanoglu, A
dc.contributor.authorGöger, F
dc.contributor.authorVatansever, HS
dc.date.accessioned2024-07-18T12:03:41Z
dc.date.available2024-07-18T12:03:41Z
dc.description.abstractAmongst all cancer types, liver cancer is the fourth leading cause of cancer mortality. It is frequently stated as hepatocellular carcinoma (HCC) and occurs in hepatocytes. Genetic alterations of hepatocytes such as Wnt/beta-catenin and JAK / STAT signaling pathways play a key role for the development of the HCC. Currently, there are a few available treatments for HCC; such treatments include transplantation, surgical resections and anticancer drugs. Most of the anti-cancer drugs target the signaling pathways for achieving an effective treatment. However, these treatments have some undesirable side effects. Thus, there is a need for discovering alternative anti-cancer agents with no or lesser side effects. Plant constituents are promising anti-cancer agents. Cynara cornigera L. contains plenty of phenolic compounds including quercetin, apigenin, etc. This study aimed to analyze the anti- cancer property of the fractionated methanol extract of the flowers of C. cornigera. All the fractions obtained were analyzed to determine the cytotoxic activity on HepG2 cells. Two of the fractions containing polyphenolic compounds had a significant cytotoxic activity related to non-canonical Wnt11 signaling pathways on HepG2 cells.
dc.identifier.issn1307-6167
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/9277
dc.language.isoEnglish
dc.publisherACG PUBLICATIONS
dc.subjectDIFFERENTIAL GENE-EXPRESSION
dc.subjectPHENOLIC-COMPOUNDS
dc.subjectIDENTIFICATION
dc.subjectCONSTITUENTS
dc.subjectPATHOGENESIS
dc.subjectWNT3A
dc.titleThe Effect of Cynara cornigera L. in HepG2 Hepatocellular Carcinoma Cells
dc.typeArticle

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