COVID-19 disease in children presenting to the pediatric emergency department: A multicenter study with 8886 cases from Turkey

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dc.contributor.authorDuman, M
dc.contributor.authorSik, N
dc.contributor.authorTeksam, O
dc.contributor.authorAkca, H
dc.contributor.authorKurt, F
dc.contributor.authorCaglar, AA
dc.contributor.authorYildiz, LA
dc.contributor.authorTasar, MA
dc.contributor.authorFidanci, I
dc.contributor.authorYayla, BCC
dc.contributor.authorYilmaz, D
dc.contributor.authorGungor, E
dc.contributor.authorDemir, S
dc.contributor.authorCokugras, H
dc.contributor.authorCebeci, SO
dc.contributor.authorOnal, P
dc.contributor.authorSaz, EU
dc.contributor.authorYurtseven, A
dc.contributor.authorUysalol, M
dc.contributor.authorYildiz, R
dc.contributor.authorGumus, S
dc.contributor.authorBal, A
dc.contributor.authorSen Bayturan, S
dc.contributor.authorZengin, N
dc.contributor.authorAtik, S
dc.contributor.authorCiftdogan, DY
dc.contributor.authorBerksoy, E
dc.contributor.authorCicek, A
dc.contributor.authorSahin, S
dc.contributor.authorKizil, MC
dc.contributor.authorKara, Y
dc.contributor.authorApa, H
dc.contributor.authorUlusoy, E
dc.contributor.authorKara, AA
dc.contributor.authorYesil, E
dc.contributor.authorErdem, M
dc.contributor.authorTuran, C
dc.contributor.authorArslanoglu, S
dc.contributor.authorDuyu, M
dc.contributor.authorBesli, GE
dc.contributor.authorArslan, G
dc.contributor.authorOflu, AT
dc.contributor.authorCelegen, M
dc.contributor.authorBuldu, E
dc.contributor.authorPiskin, IE
dc.contributor.authorKardes, H
dc.contributor.authorYilmaz, HL
dc.contributor.authorYildizdas, D
dc.contributor.authorGokulu, G
dc.contributor.authorCay, P
dc.contributor.authorOzer, U
dc.contributor.authorGuleryuz, OD
dc.contributor.authorColak, O
dc.contributor.authorGuneysu, ST
dc.date.accessioned2024-07-18T12:08:18Z
dc.date.available2024-07-18T12:08:18Z
dc.description.abstractBackground: The aim was to evaluate the epidemiological, clinical, laboratory, and radiologic data of children with SARS-CoV-2 positivity by polymerase chain reaction (PCR) together with treatment strategies and clinical out-comes and to evaluate cases of multisystem inflammatory syndrome in children (MIS-C) in this population.Methods: This was a multicenter retrospective observational cohort study performed in the pediatric emergency departments of 19 tertiary hospitals. From March 11, 2020, to May 31, 2021, children who were diagnosed with confirmed nasopharyngeal/tracheal specimen SARS-CoV-2 PCR positivity or positivity for serum-specific anti-bodies against SARS-CoV-2 were included. Demographics, presence of chronic illness, symptoms, history of con-tact with SARS-CoV-2 PCR-positive individuals, laboratory and radiologic investigations, clinical severity, hospital admissions, and prognosis were recorded.Results: A total of 8886 cases were included. While 8799 (99.0%) cases resulted in a diagnosis of SARS-CoV-2 with PCR positivity, 87 (1.0%) patients were diagnosed with MIS-C. Among SARS-CoV-2 PCR-positive patients, 51.0% were male and 8.5% had chronic illnesses. The median age was 11.6 years (IQR: 5.0-15.4) and 737 (8.4%) patients were aged <1 year. Of the patients, 15.5% were asymptomatic. The most common symptoms were fever (48.5%) and cough (30.7%) for all age groups. There was a decrease in the rate of fever as age increased (p < 0.001); the most common age group for this symptom was <1 year with the rate of 69.6%. There was known contact with a SARS-CoV-2 PCR-positive individual in 67.3% of the cases, with household contacts in 71.3% of those cases. In terms of clinical severity, 83 (0.9%) patients were in the severe-critical group. There was hospital admission in 1269 (14.4%) cases, with 106 (1.2%) of those patients being admitted to the pediatric intensive care unit (PICU). Among patients with MIS-C, 60.9% were male and the median age was 6.4 years (IQR: 3.9-10.4). Twelve (13.7%) patients presented with shock. There was hospital admission in 89.7% of these cases, with 29.9% of the patients with MIS-C being admitted to the PICU.Conclusion: Most SARS-CoV-2 PCR-positive patients presented with a mild clinical course. Although rare, MIS-C emerges as a serious consequence with frequent PICU admission. Further understanding of the characteristics of COVID-19 disease could provide insights and guide the development of therapeutic strategies for target groups.(c) 2022 Elsevier Inc. All rights reserved.
dc.identifier.issn0735-6757
dc.identifier.other1532-8171
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/10871
dc.language.isoEnglish
dc.publisherW B SAUNDERS CO-ELSEVIER INC
dc.titleCOVID-19 disease in children presenting to the pediatric emergency department: A multicenter study with 8886 cases from Turkey
dc.typeArticle

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