Histopathological evaluation of the urethra after the Snodgrass operation: An experimental study in rabbits
| dc.contributor.author | Genç A. | |
| dc.contributor.author | Taneli C. | |
| dc.contributor.author | Günşar C. | |
| dc.contributor.author | Türkdoǧan P. | |
| dc.contributor.author | Yilmaz O. | |
| dc.contributor.author | Arslan O.A. | |
| dc.contributor.author | Mir E. | |
| dc.date.accessioned | 2025-04-10T11:18:02Z | |
| dc.date.available | 2025-04-10T11:18:02Z | |
| dc.date.issued | 2002 | |
| dc.description.abstract | Objective: To investigate the histopathological outcome of the incised urethral plate after tubularized incised-plate urethroplasty (the Snodgrass procedure to repair hypospadias) in a hypospadiac rabbit model, as it can produce meatal and neourethral strictures, and healing with scarring. Materials and methods: The study comprised 10 male New Zealand White rabbits (2.2-2.4 kg); under general anaesthesia the ventral urethra was completely excised 1 cm from the meatus proximally and a model of hypospadias formed. A full-thickness incision was then made in the distal dorsal urethra and the two sides of the incision marked by Indian ink tattooing. After placing a feeding tube (5 F) as a urethral catheter, both urethral wings were sutured ventrally by a 7/0 polydioxanone running suture, and the penile skin approximated by 5/0 chromic catgut. At 21 days and 3 months after surgery the penises were harvested. assessed histopathologically, and compared with those from control untreated rabbits of the same age and weight. Results: In the study group the incised area of the dorsal urethra was re-epithelialized; the regional tissue and vascularity were normal. Conclusion: In this rabbit model the dorsal urethral incisions healed with no scar tissue: only the ventral suture lines had minimal fibrosis and inflammatory reaction. | |
| dc.identifier.DOI-ID | 10.1046/j.1464-410X.2002.03023.x | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/53123 | |
| dc.title | Histopathological evaluation of the urethra after the Snodgrass operation: An experimental study in rabbits | |
| dc.type | Article |