Different patterns of manic/hypomanic symptoms in depression: A pilot modification of the hypomania checklist-32 to assess mixed depression

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dc.contributor.authorPrieto M.L.
dc.contributor.authorYoungstrom E.A.
dc.contributor.authorOzerdem A.
dc.contributor.authorAltinbas K.
dc.contributor.authorQuiroz D.
dc.contributor.authorAydemir O.
dc.contributor.authorYalin N.
dc.contributor.authorGeske J.R.
dc.contributor.authorFeeder S.E.
dc.contributor.authorAngst J.
dc.contributor.authorFrye M.A.
dc.date.accessioned2025-04-10T11:10:35Z
dc.date.available2025-04-10T11:10:35Z
dc.date.issued2015
dc.description.abstractMethods The study sample consisted of 188 patients with Structured Clinical Interview for DSM-IV-TR disorders (SCID) confirmed bipolar or major depressive disorder. We modified the Hypomania Checklist-32 (mHCL-32) to assess current instead of lifetime symptoms. An Exploratory Factor Analysis (EFA) was conducted to identify clusters of mHCL-32 items that were endorsed concurrently. A Latent Class Analysis (LCA) was carried out to identify groups of patients with similar mHCL-32 item endorsement patterns.; Background There are no self-report scales that assess manic/hypomanic symptoms in patients with depression. The aim of this study was to explore the use of a modified screening instrument for bipolar disorder to assess current manic/hypomanic symptoms in patients with a depressive episode.; Results The EFA identified 3 factors: factor #1 ("elation-disinhibition-increased goal directed activity"), factor #2 ("risk-taking-impulsivity-substance use") and factor #3 (distractibility-irritability). The LCA yielded 3 classes (2 showing manic/hypomanic features). While class #1 patients endorsed more items related to disinhibition and racing thoughts, class #2 patients recognized more items associated with irritability and substance use.; Limitations Lack of an adequate gold standard measure of mixed depression to compare to, the cross-sectional design and the lack of a validation sample.; Conclusions The mHCL-32 scale allowed a comprehensive and convergent delineation of hypomanic/manic symptoms in depression. Further validation of these findings is needed. © 2014 Elsevier B.V. All rights reserved.
dc.identifier.DOI-ID10.1016/j.jad.2014.09.047
dc.identifier.urihttp://hdl.handle.net/20.500.14701/49259
dc.publisherElsevier B.V.
dc.titleDifferent patterns of manic/hypomanic symptoms in depression: A pilot modification of the hypomania checklist-32 to assess mixed depression
dc.typeArticle

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