Col IV and Fn distribution in prostatic adenocarcinoma and correlation of 67LR, MMP-9 and TIMP-1 expression with Gleason score

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dc.contributor.authorIsisag, A
dc.contributor.authorNese, N
dc.contributor.authorErmete, M
dc.contributor.authorLekili, M
dc.contributor.authorAyhan, S
dc.contributor.authorKandiloglu, AR
dc.date.accessioned2024-07-18T11:54:33Z
dc.date.available2024-07-18T11:54:33Z
dc.description.abstractOBJECTIVE: To assess the immunoreactivity of 5 proteins related to basement membrane (BM) and extracellular matrix in order to investigate whether any of them correlates with differentiation of prostatic adenocarcinoma (PAc). Two of these markers are collagen type IV (Col IV), the collagenous component of basement membrane, andfibronectin (Fn), an adhesion protein in extracellular matrix. Others are matrix metalloproteinase-9 (MMP9), a type IV collagenase, tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), which has a high affinity for A4MP-9, and 67-kd laminin receptor (67LR), which belongs to the non-integrin laminin binding receptor family. STUDY DESIGN: Forty-three PAc cases with Gleason scores ranging between 5 and 10 and 10 benign prostatic hyperplasia (BPH) cases, the control group, were included in the study. Formalin-fixed and paraffin-embedded tissue slides from each case were immunostained with the avidin-biotin-peroxidase method. Immunoreactivity was determined by means of a scoring system similar to the Gleason scoring system. RESULTS: Overexpression of Col IV, Fn, 67LR and MMP-9 was detected in PAc as compared with BPH, whereas no difference was determined in TIMP-1 expression. Among these, only 67LR correlated statistically with Gleason score. CONCLUSION: Expression of 67LR in tumor cells was significantly increased in parallel to tumor grade. This may be useful in microscopic evaluation of PAc.
dc.identifier.issn0884-6812
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/6453
dc.language.isoEnglish
dc.publisherSCI PRINTERS & PUBL INC
dc.subject67-KD LAMININ RECEPTOR
dc.subjectBREAST-CARCINOMA PROGRESSION
dc.subjectINDEPENDENT PROGNOSTIC VALUE
dc.subjectCELL LUNG-CANCER
dc.subjectTISSUE INHIBITOR
dc.subjectBASEMENT-MEMBRANE
dc.subjectMATRIX METALLOPROTEINASES
dc.subjectGASTRIC-CARCINOMA
dc.subject1-MATRIX METALLOPROTEINASE
dc.subjectINTRAEPITHELIAL NEOPLASIA
dc.titleCol IV and Fn distribution in prostatic adenocarcinoma and correlation of 67LR, MMP-9 and TIMP-1 expression with Gleason score
dc.typeArticle

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