Association of platelet-activating factor acetylhydrolase gene polymorphism with premature coronary artery disease in Turkish patients

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dc.contributor.authorŞekuri C.
dc.contributor.authorÇam F.S.
dc.contributor.authorTengiz I.
dc.contributor.authorErcan E.
dc.contributor.authorBayturan Ö.
dc.contributor.authorBerdeli A.
dc.date.accessioned2024-07-22T08:23:24Z
dc.date.available2024-07-22T08:23:24Z
dc.date.issued2006
dc.description.abstractObjective: Platelet-activating factor (PAF) is a phospholipid with multiple actions that is involved in inflammatory diseases as well as in atherogenesis. It is inactivated by a plasma enzyme, PAF-acetylhydrolase (PAF-AH). Deficiency of this enzyme in plasma is caused by a missense mutation in the gene (G994T). The aim of this study was to investigate association of this mutation with premature coronary artery disease (CAD). Methods: One hundred and fifteen unrelated Turkish patients with a diagnosis of premature CAD and 128 unrelated healthy subjects were enrolled in this study. Genotyping was performed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). Results: The prevalence of the G994T mutation in the patients was 2.60 % (heterozygote), and 0 % in the controls. There was no significant difference in allele frequency and genotype distribution among the study groups. Conclusion: The G9943T mutation in the plasma PAF acetylhydrola se gene is not associated with premature CAD in Turkish subjects.
dc.identifier.issn13028723
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19526
dc.language.isoEnglish
dc.subject1-Alkyl-2-acetylglycerophosphocholine Esterase
dc.subjectCase-Control Studies
dc.subjectCoronary Arteriosclerosis
dc.subjectEuropean Continental Ancestry Group
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMutation
dc.subjectPolymerase Chain Reaction
dc.subjectPolymorphism, Genetic
dc.subjectPolymorphism, Restriction Fragment Length
dc.subjectPrevalence
dc.subjectTurkey
dc.subject1 alkyl 2 acetylglycerophosphocholine esterase
dc.subjectcholesterol
dc.subjectDNA fragment
dc.subjectgenomic DNA
dc.subjecthigh density lipoprotein cholesterol
dc.subjectlow density lipoprotein cholesterol
dc.subjecttriacylglycerol
dc.subjectadult
dc.subjectarticle
dc.subjectbody mass
dc.subjectcontrolled study
dc.subjectcoronary artery disease
dc.subjectcoronary risk
dc.subjectdiabetes mellitus
dc.subjectDNA polymorphism
dc.subjectfamily history
dc.subjectfemale
dc.subjectgene frequency
dc.subjectgene mutation
dc.subjectgenetic association
dc.subjectgenotype
dc.subjectheterozygosity
dc.subjecthuman
dc.subjecthypertension
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpolymerase chain reaction
dc.subjectprevalence
dc.subjectprotein blood level
dc.subjectrestriction fragment length polymorphism
dc.subjectsmoking habit
dc.subjectTurkey (republic)
dc.subjectvascular disease
dc.titleAssociation of platelet-activating factor acetylhydrolase gene polymorphism with premature coronary artery disease in Turkish patients
dc.typeArticle

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