The cytotoxic, neurotoxic, apoptotic and antiproliferative activities of extracts of some marine algae on the MCF-7 cell line
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Date
2014
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Abstract
We investigated the cytotoxic, neurotoxic, apoptotic and antiproliferative effects of extracts from Petalonia fascia, Jania longifurca and Halimeda tuna on the MCF-7 breast cancer cell line. J. longifurca extracts were more toxic than those of P. fascia and H. tuna. The algal extracts showed significant toxic effects at different dilutions. The toxic effects were due to increased oxidative stress and resulted in apoptosis. Algal toxicity may exert negative effects through the food chain or by direct interaction. Algal toxicity also has potential for cancer therapy. The toxic effects that we observed may be especially important for therapy for breast tumors. © 2014 The Biological Stain Commission.
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Keywords
Antineoplastic Agents , Apoptosis , Breast Neoplasms , Cell Proliferation , Cell Survival , Chlorophyta , Female , Humans , Lethal Dose 50 , MCF-7 Cells , Neurotoxins , Phaeophyta , Plant Extracts , Rhodophyta , Seawater , algae , Halimeda tuna , Jania longifurca , Petalonia fascia , antineoplastic agent , neurotoxin , plant extract , sea water , apoptosis , Breast Neoplasms , brown alga , cell proliferation , cell survival , chemistry , drug effects , female , green alga , human , LD50 , MCF 7 cell line , microbiology , pathology , red alga