The cytotoxic, neurotoxic, apoptotic and antiproliferative activities of extracts of some marine algae on the MCF-7 cell line

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dc.contributor.authorKurt O.
dc.contributor.authorÖzdal-Kurt F.
dc.contributor.authorTuʇlu M.I.
dc.contributor.authorAkçora C.M.
dc.date.accessioned2024-07-22T08:14:32Z
dc.date.available2024-07-22T08:14:32Z
dc.date.issued2014
dc.description.abstractWe investigated the cytotoxic, neurotoxic, apoptotic and antiproliferative effects of extracts from Petalonia fascia, Jania longifurca and Halimeda tuna on the MCF-7 breast cancer cell line. J. longifurca extracts were more toxic than those of P. fascia and H. tuna. The algal extracts showed significant toxic effects at different dilutions. The toxic effects were due to increased oxidative stress and resulted in apoptosis. Algal toxicity may exert negative effects through the food chain or by direct interaction. Algal toxicity also has potential for cancer therapy. The toxic effects that we observed may be especially important for therapy for breast tumors. © 2014 The Biological Stain Commission.
dc.identifier.DOI-ID10.3109/10520295.2014.917199
dc.identifier.issn10520295
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16603
dc.language.isoEnglish
dc.publisherInforma Healthcare
dc.subjectAntineoplastic Agents
dc.subjectApoptosis
dc.subjectBreast Neoplasms
dc.subjectCell Proliferation
dc.subjectCell Survival
dc.subjectChlorophyta
dc.subjectFemale
dc.subjectHumans
dc.subjectLethal Dose 50
dc.subjectMCF-7 Cells
dc.subjectNeurotoxins
dc.subjectPhaeophyta
dc.subjectPlant Extracts
dc.subjectRhodophyta
dc.subjectSeawater
dc.subjectalgae
dc.subjectHalimeda tuna
dc.subjectJania longifurca
dc.subjectPetalonia fascia
dc.subjectantineoplastic agent
dc.subjectneurotoxin
dc.subjectplant extract
dc.subjectsea water
dc.subjectapoptosis
dc.subjectBreast Neoplasms
dc.subjectbrown alga
dc.subjectcell proliferation
dc.subjectcell survival
dc.subjectchemistry
dc.subjectdrug effects
dc.subjectfemale
dc.subjectgreen alga
dc.subjecthuman
dc.subjectLD50
dc.subjectMCF 7 cell line
dc.subjectmicrobiology
dc.subjectpathology
dc.subjectred alga
dc.titleThe cytotoxic, neurotoxic, apoptotic and antiproliferative activities of extracts of some marine algae on the MCF-7 cell line
dc.typeArticle

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