Effects of adrenomeduline and ramp2 on the lung of mice exposed to total body radiation

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dc.contributor.authorOzbilgin, MK
dc.contributor.authorKaraman, GZ
dc.contributor.authorGencur, S
dc.contributor.authorGumustepe, E
dc.contributor.authorKurtman, C
dc.date.accessioned2024-07-18T12:03:01Z
dc.date.available2024-07-18T12:03:01Z
dc.description.abstractBackground: Adrenomedullin (AM) and its receptor, receptor activity-modifying protein (RAMP) 2 have pleiotropic regulatory functions in normal tissue and cancer tissue. AM is produced and secreted both numerous stromal cells and tumor cells. This study aims to investigate a possible role of AM and RAMP2 in the radiation exposure in the normal lung tissue. Materials and Methods: Four groups with 6 male adult Swiss Albino mice per group were investigated. The mice were subjected to a 500 cGy single-dose radiation exposure in the total body radiation device and lung tissues were collected. 1, 2, and 7 days after radiation exposure, with 1 reference group which was not exposed to radiation. Results: The general histology and the immunohistochemistry of the tissue samples prepared with anti-AM, anti-RAMP2, and monoclonal antibodies were investigated, yielding a statistically significant increase for AM on day 3 and for RAMP2 on day 1 after radiation exposure. Conclusion: The observed increase of AM and RAMP2 concentrations in the normal tissue matrix after radiation exposure may play a role in the side effects of radiotherapy.
dc.identifier.issn2322-3243
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/8840
dc.language.isoEnglish
dc.publisherIJRR-IRANIAN JOURNAL RADIATION RES
dc.subjectENDOTHELIAL ADRENOMEDULLIN-RAMP2 SYSTEM
dc.subjectHYPOTENSIVE PEPTIDE
dc.subjectVASCULAR INTEGRITY
dc.subjectCANCER CELLS
dc.subjectKAPPA-B
dc.subjectGROWTH
dc.subjectANGIOGENESIS
dc.subjectEXPRESSION
dc.subjectVEGF
dc.titleEffects of adrenomeduline and ramp2 on the lung of mice exposed to total body radiation
dc.typeArticle

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