Increased Mean Platelet Volume in Hypertrophic Cardiomyopathy

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dc.contributor.authorIcli, A
dc.contributor.authorAksoy, F
dc.contributor.authorDogan, A
dc.contributor.authorArslan, A
dc.contributor.authorAkcay, S
dc.contributor.authorYücel, H
dc.contributor.authorErsoy, I
dc.contributor.authorGorgulu, O
dc.date.accessioned2024-07-18T12:05:06Z
dc.date.available2024-07-18T12:05:06Z
dc.description.abstractThromboembolic events may be seen in patients with hypertrophic cardiomyopathy (HCM). We investigated the mean platelet volume (MPV), an indicator of platelet activation in patients with HCM. This study included 112 patients with HCM, in which 40 were patients with hypertrophic obstructive cardiomyopathy (HOCM), and 106 were control participants. The MPV was significantly higher in patients with HCM than in controls (9.1 +/- 0.3 vs 7.9 +/- 0.3 fL, P = .01). In the subgroup analyses, MPV was also higher in patients with HOCM compared to those with hypertrophic nonobstructive cardiomyopathy (HNCM; 9.3 +/- 0.3 vs 9.0 +/- 0.2 fL, P = .01). Similarly, patients with HNCM had higher MPV values than controls (9.0 +/- 0.2 vs 7.9 +/- 0.3 fL, P = .01). The MPV was significantly and positively correlated with left ventricular outflow tract (LVOT) obstruction (r = .42, P = .001) and septal thickness (r =.62, P = .001). In linear regression analysis, MPV was independently associated only with septal thickness (beta = .07, 95% confidence interval: 0.04-0.09, P = .001). The MPV can be elevated in patients with HCM regardless of the obstruction of LVOT and may be associated with the severity of septal thickness.
dc.identifier.issn0003-3197
dc.identifier.other1940-1574
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/9549
dc.language.isoEnglish
dc.publisherSAGE PUBLICATIONS INC
dc.subjectENDOTHELIAL DYSFUNCTION
dc.subjectRISK
dc.subjectACTIVATION
dc.subjectBIOMARKERS
dc.subjectSTENOSIS
dc.subjectDISEASE
dc.subjectHEALTH
dc.titleIncreased Mean Platelet Volume in Hypertrophic Cardiomyopathy
dc.typeArticle

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