Investigating of Acute and Chronic Effects of Oxaliplatin on Rat Ocular Tissues
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Date
2019
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Abstract
Objective: Visual disturbances occurring during cancer treatment with oxaliplatin (OXA) have been previouslyreported in some of case presentations. This study investigates the ocular toxicity of OXA on rat eye tissues by usinghistopathological staining. Additionally, the reversibility of findings, if there is any, were assessed in groups withwaiting periods.Method: Six-8 month-old rats have been separated into five groups. Acute OXA treatment (4 mg/kg) has beenadministered on days 1, 3 and 5th days; consequently, the eye samples were obtained on 7th and 14th days of thestudy. Chronic OXA treatment (4 mg/kg) has been administered for 4 weeks (two days of week); the rats weresacrificed on 28th day and 21 days after completing administration of drug. One group was used as a control.Results: The most striking irreversible-features of OXA treatment were endothelial polypoid proliferation of thevessel, neo-vascularisation of cornea, capillarisation of optic nerve and, degeneration of retinal nerve fibre layer atseveral degrees of severity.Conclusion: OXA treatment can be responsible for sight threatening side effects by influencing different parts ofthe ophthalmic system; therefore, oncologists and ophthalmologists should keep in mind the irreversibl-ophthalmicadverse effects of OXA treatment in oncology patients.