Assessment of PSA-Age volume score in predicting positive prostate biopsy findings in Turkey
| dc.contributor.author | Uçer, O | |
| dc.contributor.author | Yücetas, U | |
| dc.contributor.author | Çelen, I | |
| dc.contributor.author | Toktas, G | |
| dc.contributor.author | Müezzinoglu, T | |
| dc.date.accessioned | 2024-07-18T12:01:26Z | |
| dc.date.available | 2024-07-18T12:01:26Z | |
| dc.description.abstract | Objectives: To evaluate PSA-age volume (AV) scores in predicting positive prostate biopsy findings in Turkey. Materials and Methods: PSA-AV was calculated by multiplying the patient's age by the prostate volume and dividing it by the PSA level. Sensitivities and specificities of the PSA-AV were assessed by retrospective analysis of findings from 4,717 prostate biopsies. Results: The population's average age was 63.71 +/- 7.63 years, the mean PSA level was 9.73 +/- 17.01ng/mL, the mean prostate volume was 44.46 +/- 23.88 cm(3). Of the 4,717 prostate biopsies, 1,171 biopsy specimens (24.8%) were positive for prostate cancer. A PSA-AV score of 700 had a sensitivity and specificity of 95% and 15%, respectively. These values were similar to the sensitivity and specificity for a PSA cut-off of 4ng/mL (94% and 13%, respectively). Although the sensitivity of a PSA-AV cut-off of 700 in patients over 60 years was similar to the PSA cut-off of 4ng/mL and the age-adjusted PSA, in patients < 60 years, its sensitivity was higher. While the sensitivities of a PSA-AV cut- off of 700 in patients with low prostate volume was higher than a PSA cut-off of 4ng/mL, the sensitivities of both methods with moderate prostate volumes were similar. Conclusions: Considering all the biopsies, the sensitivity and specificity of a PSA-AV of 700 for predicting positive biopsy findings were similar to a PSA of 4ng/mL. We suggest the PSA-AV cut-off of 700 should only be used in patients younger than 60 with low prostate volumes (<20cm(3)). | |
| dc.identifier.issn | 1677-5538 | |
| dc.identifier.other | 1677-6119 | |
| dc.identifier.uri | http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/8418 | |
| dc.language.iso | English | |
| dc.publisher | BRAZILIAN SOC UROL | |
| dc.subject | ANTIGEN | |
| dc.subject | CANCER | |
| dc.subject | SERUM | |
| dc.subject | MEN | |
| dc.title | Assessment of PSA-Age volume score in predicting positive prostate biopsy findings in Turkey | |
| dc.type | Article |