Familial Mediterranean Fever Mutation Analysis in Pediatric Patients With İnflammatory Bowel Disease: A Multicenter Study

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dc.contributor.authorNafiye URGANCI
dc.contributor.authorFunda OZGENC
dc.contributor.authorZarife KULOĞLU
dc.contributor.authorHasan YÜKSEKKAYA
dc.contributor.authorSinan SARI
dc.contributor.authorTülay ERKAN
dc.contributor.authorZerrin ÖNAL
dc.contributor.authorGönül ÇALTEPE
dc.contributor.authorMustafa AKÇAM
dc.contributor.authorDuran ARSLAN
dc.contributor.authorNur ARSLAN
dc.contributor.authorReha ARTAN
dc.contributor.authorAyşen AYDOĞAN
dc.contributor.authorNecati BALAMTEKİN
dc.contributor.authorMaşallah BARAN
dc.contributor.authorGökhan BAYSOY
dc.contributor.authorMurat ÇAKIR
dc.contributor.authorBuket DALGIÇ
dc.contributor.authorYaşar DOĞAN
dc.contributor.authorÖzlem DURMAZ
dc.contributor.authorÇiğdem ECEVIT
dc.contributor.authorMakbule EREN
dc.contributor.authorSelim GÖKÇE
dc.contributor.authorFulya GÜLERMAN
dc.contributor.authorFigen GÜRAKAN
dc.contributor.authorSamil HIZLI
dc.contributor.authorIshak IŞIK
dc.contributor.authorAyhan Gazi KALAYCI
dc.contributor.authorAydan KANSU
dc.contributor.authorTufan KUTLU
dc.contributor.authorHamza KARABİBER
dc.contributor.authorErhun KASIRGA
dc.contributor.authorGünsel KUTLUK
dc.contributor.authorFerdağ ÖZBAY HOŞNUT
dc.contributor.authorHasan ÖZEN
dc.contributor.authorTanju ÖZKAN
dc.contributor.authorYeşim ÖZTÜRK
dc.contributor.authorÖzlem BEKEM SOYLU
dc.contributor.authorEngin TUTAR
dc.contributor.authorGökhan TÜMGÖR
dc.contributor.authorFatih ÜNAL
dc.contributor.authorMeltem UGRAŞ
dc.contributor.authorGonca ÜSTÜNDAĞ
dc.contributor.authorAytaç YAMAN
dc.contributor.authorTurkish IBD Study Group
dc.date.accessioned2024-07-24T09:10:44Z
dc.date.available2024-07-24T09:10:44Z
dc.date.issued2021
dc.description.abstractBackground: The aim of the study was to evaluate familial Mediterranean fever (FMF) mutation analysis in pediatric patients with inflammatory bowel disease (IBD). The relation between MEFV mutations and chronic inflammatory diseases has been reported previously. Methods: Children with IBD (334 ulcerative colitis (UC), 224 Crohn’s disease (CD), 39 indeterminate colitis (IC)) were tested for FMF mutations in this multicenter study. The distribution of mutations according to disease type, histopathological findings, and disease activity indexes was determined. Results: A total of 597 children (mean age: 10.8 ± 4.6 years, M/F: 1.05) with IBD were included in the study. In this study, 41.9% of the patients had FMF mutations. E148Q was the most common mutation in UC and CD, and M694V in IC (30.5%, 34.5%, 47.1%, respectively). There was a significant difference in terms of endoscopic and histopathological findings according to mutation types (homozygous/heterozygous) in patients with UC (P < .05). There was a statistically significant difference between colonoscopy findings in patients with or without mutations (P=.031, P=.045, respectively). The patients with UC who had mutations had lower Pediatric Ulcerative Colitis Activity Index (PUCAI) scores than the patients without mutations (P=.007). Conclusion: Although FMF mutations are unrelated to CD patients, but observed in UC patients with low PUCAI scores, it was established that mutations do not have a high impact on inflammatory response and clinical outcome of the disease.
dc.identifier.DOI-ID10.5152/tjg.2021.20057
dc.identifier.issn1300-4948
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/23137
dc.language.isoeng
dc.titleFamilial Mediterranean Fever Mutation Analysis in Pediatric Patients With İnflammatory Bowel Disease: A Multicenter Study
dc.typeAraştırma Makalesi

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