G protein β3 subunit gene polymorphism in Turkish hypertensives

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dc.contributor.authorAlioglu, E
dc.contributor.authorErcan, E
dc.contributor.authorTengiz, I
dc.contributor.authorYildiz, A
dc.contributor.authorTürk, UO
dc.contributor.authorSaygi, S
dc.contributor.authorÇam, FS
dc.contributor.authorBerdeli, A
dc.date.accessioned2024-07-18T12:06:03Z
dc.date.available2024-07-18T12:06:03Z
dc.description.abstractObjective: G protein is one of the most important regulators of intracellular signaling pathways. C825T polymorphism of G protein (33 subunit is associated with increased intracellular signal transduction. The 825T allele has been found associated with a variety of cardiovascular risk factors, including hypertension. The aim of the present study was to investigate the association between the C825T polymorphism of the G protein beta 3 subunit and essential hypertension in Turkish population. Methods: This cross-sectional, case-controlled study included 209 patients with essential hypertension (Patient group) and 82 subjects with normal blood pressure (Control group). The G protein 133 subunit C825T gene polymorphism was determined by polymerase chain reaction. Hypertension was defined according to JNC VII criteria. Statistical analysis was performed using Chi square and unpaired t tests. Logistic regression analysis was used to study association between hypertension and genotypes. Results: We found that the frequencies of the G protein 133 subunit C825T polymorphism in hypertensive and control groups were 17.7%, 59.3%, 23.0% and 32.9%, 48.8%, 18.3%, (CC, CT, TT) respectively (chi(2)=7.963, p=0.019). In the multivariate logistic regression analysis CT genotype had 2.2 (OR=2.262, 95% CI 1.228-4.167, p=0.009), and TT genotype had 2.3 times (OR=2.335, 95% CI 1.089-5.008, p=0.029) greater risk of hypertension compared to CC genotype. Conclusion: It seems that the G protein (33 subunit C825T gene polymorphism is associated with systolic and diastolic blood pressure. Furthermore, the study indicates that the G protein 133 subunit may be a susceptible gene to essential hypertension. (Anadolu Kardiyol Derg 2008; 8: 337-5)
dc.identifier.issn2149-2263
dc.identifier.other2149-2271
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/10161
dc.language.isoEnglish
dc.publisherTURKISH SOC CARDIOLOGY
dc.subjectC825T POLYMORPHISM
dc.subjectBLOOD-PRESSURE
dc.subjectGNB3 GENE
dc.subjectASSOCIATION
dc.subjectOBESITY
dc.subjectVARIANT
dc.subjectALLELE
dc.titleG protein β3 subunit gene polymorphism in Turkish hypertensives
dc.typeArticle

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