Effects of sevofluran on cell division and levels of sister chromatid exchange; [Die wirkung von sevofluran auf zellteilung, mitose-index (MI) und austausch der schwesterchromatide (sister chromatide exchange SCE)]

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dc.contributor.authorLüleci N.
dc.contributor.authorSakarya M.
dc.contributor.authorTopçu I.
dc.contributor.authorLüleci E.
dc.contributor.authorErinçler T.
dc.contributor.authorSolak M.
dc.date.accessioned2024-07-22T08:24:02Z
dc.date.available2024-07-22T08:24:02Z
dc.date.issued2005
dc.description.abstractObjective: Purpose of the study was to investigate the mitotic index (MI) and sister chromatid exchange (SCE) levels to identify the mutagenic and carcinogenic effects of sevoflurane (sevoflurane). Methods: 42 non-smoking male and female turkish patients of ASA-risk I and II were included. The patients received an anaesthesia induction with 8% sevoflurane in 100% oxygen ("tidal volume methode") and 0,1 mg/kg BW vecuronium for neuromuscular block and endotracheal intubation. Anaesthesia was maintained with 2.0-2.5 sevoflurane in 60% N2O and 40% O2. Four 5 ml venous blood samples werde taken: before induction (control), 60 minutes, 24 hours and 5 days after sevoflurane anesthesia. Samples were prepared according to the periferic blood culture assay, modified by Morhead and co-workers, and levels of MI and SCE were examined. Results: 60 minutes after sevoflurane-anaesthesia a significant decrease of MI was found compared to controls (p < 0.01). This depression was lower after 24 hours (p < 0.05) and reversible after 5 days. SCE increased significantly during 60 minutes of anaesthesia (p < 0.001), was also lower after 24 hours (5.6 ± 2.4 vs. 4.4 ± 1.7) and returned to normal levels after 5 days (p > 0.05). Conclusion: The application of sevoflurane for anaesthesia may influence the cell division in humans and may have a mutagenic effect on DNA at the cell level, which is reversible.
dc.identifier.DOI-ID10.1055/s-2005-861138
dc.identifier.issn09392661
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19790
dc.language.isoGerman
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAnesthetics, Inhalation
dc.subjectCell Division
dc.subjectChromosomes
dc.subjectDNA
dc.subjectFemale
dc.subjectHumans
dc.subjectLymphocytes
dc.subjectMale
dc.subjectMethyl Ethers
dc.subjectMiddle Aged
dc.subjectMitosis
dc.subjectMutagenicity Tests
dc.subjectSister Chromatid Exchange
dc.subjectinhalation anesthetic agent
dc.subjectneuromuscular blocking agent
dc.subjectsevoflurane
dc.subjectvecuronium
dc.subjectanesthesia induction
dc.subjectarticle
dc.subjectcell division
dc.subjectchromosome aberration
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjectfemale
dc.subjecthuman
dc.subjecthuman cell
dc.subjectinhalation anesthesia
dc.subjectmale
dc.subjectmitosis
dc.subjectmutagenicity
dc.subjectsister chromatid exchange
dc.titleEffects of sevofluran on cell division and levels of sister chromatid exchange; [Die wirkung von sevofluran auf zellteilung, mitose-index (MI) und austausch der schwesterchromatide (sister chromatide exchange SCE)]
dc.typeArticle

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