Changes in the plasma activities of protein C and protein S during pregnancy

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dc.contributor.authorOruç, S
dc.contributor.authorSaruç, M
dc.contributor.authorKoyuncu, FM
dc.contributor.authorÖzdemir, E
dc.date.accessioned2024-07-18T11:49:49Z
dc.date.available2024-07-18T11:49:49Z
dc.description.abstractThe objective of the study was to determine the changes in the plasma activities of protein C and protein S that occur during normal pregnancy. In this prospective cross-sectional study, plasma activities of protein C and protein S were measured in 32 normal pregnant women in the first, second and third trimester and 6 weeks after delivery; There was a significant fall in protein C and protein S activities during normal pregnancy compared with the post-puerperal period. The activities of protein C and protein S also gradually decreased throughout pregnancy (p < 0.01). Increasing plasma volume during normal pregnancy and its dilutional effect might play some role in the low activities of protein S observed. The normal falls in protein S and protein C activities make it difficult to diagnose protein S and C deficiency during pregnancy. Based on our findings, if a woman has a thromboembolic event during pregnancy; testing for a definitive diagnosis of protein C or protein S deficiency or functional failure should be delayed until at least 6 weeks postpartum.
dc.identifier.issn0004-8666
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/4310
dc.language.isoEnglish
dc.publisherAUSTRALIAN NZ J OBSTET GYNAEC
dc.subjectC4B-BINDING PROTEIN
dc.subjectANTITHROMBIN-III
dc.subjectCOAGULATION
dc.subjectRESISTANCE
dc.subjectDEFICIENCY
dc.subjectFIBRINOLYSIS
dc.subjectINHIBITORS
dc.titleChanges in the plasma activities of protein C and protein S during pregnancy
dc.typeArticle

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