Effect of monocyte chemoattractant protein-1 (MCP-1) gene polymorphism in Turkish patients with premature coronary artery disease

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dc.contributor.authorCam, FS
dc.contributor.authorSekuri, C
dc.contributor.authorSagcan, A
dc.contributor.authorErcan, E
dc.contributor.authorTengiz, S
dc.contributor.authorAliogiu, E
dc.contributor.authorBerdeli, A
dc.date.accessioned2024-07-18T12:03:55Z
dc.date.available2024-07-18T12:03:55Z
dc.description.abstractObjectives. It has been suggested that monocyte chemoattractant protein-1 (MCP-1) is important in the initiation of atherosclerosis and crucial in monocyte recruitment into the subendothelial lesions. Recent studies have demonstrated that MCP-1 -2518 A>G polymorphism is associated with susceptibility to coronary artery disease (CAD). Since there are conflicting reports on the possible association of MCP-1 -2518 A>G polymorphism with CAD, we investigated the role of this polymorphism in Turkish patients with premature CAD. Material and methods. Genomic DNA was collected from 171 premature CAD patients and 151 healthy individuals. MCP-1 -2518 A>G polymorphism was genotyped using the PCR-RFLP method. Results. There were no differences between genotype distribution and allele frequencies in the premature CAD and control groups (AA: 49.7%; AG: 40.3%; GG: 10.0% in premature CAD groups and AA: 53.7%; AG: 34.4%; GG: 11.9% in controls; p = 0.53). The prevalence of the G allele was 0.302 in patients and 0.291 in controls. Conclusions. Our data demonstrate that MCP-1 -2518 A>G polymorphism is not associated with premature CAD in Turkish patients. Further studies are needed to elucidate the role of this polymorphism in the pathogenesis of CAD in various populations.
dc.identifier.issn0036-5513
dc.identifier.other1502-7686
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/9453
dc.language.isoEnglish
dc.publisherTAYLOR & FRANCIS LTD
dc.subjectREGULATORY REGION
dc.subjectPROMOTER-2518 POLYMORPHISM
dc.subjectMYOCARDIAL-INFARCTION
dc.subjectALLELIC FREQUENCY
dc.subjectPLASMA-LEVELS
dc.subjectATHEROSCLEROSIS
dc.subjectRISK
dc.subjectEXPRESSION
dc.subjectSUSCEPTIBILITY
dc.subjectASSOCIATION
dc.titleEffect of monocyte chemoattractant protein-1 (MCP-1) gene polymorphism in Turkish patients with premature coronary artery disease
dc.typeArticle

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