Changes in the plasma activities of protein C and protein S during pregnancy

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dc.contributor.authorOruç S.
dc.contributor.authorSaruç M.
dc.contributor.authorKoyuncu F.M.
dc.contributor.authorÖzdemir E.
dc.date.accessioned2025-04-10T11:18:17Z
dc.date.available2025-04-10T11:18:17Z
dc.date.issued2000
dc.description.abstractThe objective of the study was to determine the changes in the plasma activities of protein C and protein S that occur during normal pregnancy. In this prospective cross-sectional study, plasma activities of protein C and protein S were measured in 32 normal pregnant women in the first, second and third trimester and 6 weeks after delivery. There was a significant fall in protein C and protein S activities during normal pregnancy compared with the post-puerperal period. The activities of protein C and protein S also gradually decreased throughout pregnancy (p < 0.01). Increasing plasma volume during normal pregnancy and its dilutional effect might play some role in the low activities of protein S observed. The normal falls in protein S and protein C activities make it difficult to diagnose protein S and C deficiency during pregnancy. Based on our findings, if a woman has a thromboembolic event during pregnancy, testing for a definitive diagnosis of protein C or protein S deficiency or functional failure should be delayed until at least 6 weeks postpartum.
dc.identifier.DOI-ID10.1111/j.1479-828X.2000.tb01179.x
dc.identifier.urihttp://hdl.handle.net/20.500.14701/53353
dc.titleChanges in the plasma activities of protein C and protein S during pregnancy
dc.typeArticle

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