The effect of levosimendan on weaning from cardiopulmonary bypass and early hemodynamic parameters in patients with compromised left ventricular function; [Kötü sol ventrikül fonksiyonlu hastalarda levosimendanin kardiyopulmoner baypastan ayrilma ve erken dönem hemodinamik parametreler Üzerine etkileri]
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2006
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Abstract
In this study we determined the effects of levosimendan on hemodynamic parameters during weaning from cardiopulmonary bypass (CPB) and in the early postoperative period in patients with compromised left ventricular-function. Charts of 18 patients with an ejection fraction of ≤30 % who underwent elective coronary artery bypass (CABG) surgery were reviewed. Eight (Group L) had received a loading dose of levosimendan (6 μg kg-1) within 10 minutes after removal of the cross clamp, followed by an infusion (0.1 mcg kg-1 min-1). Control patients (n=10, Group C) received dopamine, dobutamine or adrenaline. Hemodynamic parameters during the early postoperative period were compared. Cardiac index (CI) was significantly higher than baseline in both groups at one and six hours after removal of the cross clamp (p<0.05). CI was significantly greater, and SVRI and PVRI were significantly lower, in Group L at both one and six hours (p<0.001). In conclusion, the use of levosimendan was associated with more favourable hemodynamic effects in patients with compromised left ventricular function during weaning from CPB and in the early postoperative period after CABG surgery.
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adrenalin , amiodarone , aritmal , diazepam , dobutamine , dopamine , etomidate , fentanyl , levosimendan , lidocaine , midazolam , midazolam maleate , sevoflurane , unclassified drug , vecuronium , adult , aged , artery clamp , cardiopulmonary bypass , controlled study , coronary artery bypass surgery , drug effect , drug infusion , elective surgery , female , heart ejection fraction , heart index , heart left ventricle performance , hemodynamic parameters , human , loading drug dose , major clinical study , male , medical record review , postoperative period , review , weaning