Does the anti-migraine drug rizatriptan affect early neural tube development in chick embryos?
| dc.contributor.author | Sayin M. | |
| dc.contributor.author | Gurgen G.S. | |
| dc.contributor.author | Sayin S.S. | |
| dc.contributor.author | Guvenc G. | |
| dc.contributor.author | Yuceer N. | |
| dc.date.accessioned | 2025-04-10T11:07:42Z | |
| dc.date.available | 2025-04-10T11:07:42Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | AIM: To investigate the impact of rizatriptan on neural tube development using early chick embryos as a model organism. MATERIAL and METHODS: A total of 36 pathogen-free Leghorn chicken eggs were selected and categorized in three groups: sham, therapeutic, and supra-therapeutic. After 24 hours, the eggs were opened and injected with sterile drugs, and then reclosed using plastic tape. After a period of 72 hours, the eggs were opened and assessed using the Hamburger-Hamilton chick embryology classification method. TUNEL staining was used to identify apoptosis, and hematoxylin-eosin staining was used to investigate neural tube closure. RESULTS: Treatment with rizatriptan significantly slowed down neural tube development. The supra-therapeutic group showed neural tube closure defects. CONCLUSION: Rizatriptan had a negative effect on neural tube closure. Further research is needed to identify a safe and effective drug for treating migraines during pregnancy. © 2019 Turkish Neurosurgical Society. | |
| dc.identifier.DOI-ID | 10.5137/1019-5149.JTN.23431-18.1 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/47546 | |
| dc.publisher | Turkish Neurosurgical Society | |
| dc.title | Does the anti-migraine drug rizatriptan affect early neural tube development in chick embryos? | |
| dc.type | Article |