Vitamin D level in Patients with Prediabetes
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Date
2020
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Abstract
Objective: Vitamin D deficiency may cause glucose intolerance, diabetes mellitus, and metabolic syndrome. However, there are conflicting data the relationship between vitamin D levels and prediabetes in the literature. Our aim in this study is to evaluate serum 25-hydroxyvitamin D levels in prediabetic patients and to determine if vitamin D deficiency or insufficiency is a factor for developing prediabetes.Materials and Methods: Our study included a total of 220 patients, including 85 with isolated Impaired Fasting Glucose (IFG), 50 with isolated Impaired Glucose Tolerance (IGT), and 85 with combined IFG and IGT, and 80 healthy normoglycemic individuals similar in age, gender and BMI. Results: The mean vitamin D levels between the patient group diagnosed as IGT and IFG+IGT and the control group were statistically significantly different (IGT: 11.69±6.48 ng/ml vs. control group: 16.63±9.78 ng/ml, p<0.007, IFG+IGT: 13.22±7.24 ng/ml vs. control group: 16.63±9.78 ng/ml, p<0.047, respectively). Lower 25-hydroxy vitamin D levels were associated with a higher risk of IGT (OR 2.57, 95% CI 1.01-6.53, p=0.043). 25-hydroxyvitamin D levels were similar in the control and IFG groups. No significant difference was observed between the IFG and the control group (13.90±8.89 ng/ml vs. the control group: 16.63±9.78 ng/ml, p<0.158). Moreover, no significant difference was observed between the IFG, IGT, and IFG+IGT groups, either. Conclusion: In this study, it was observed that vitamin D insufficiency and deficiency increased the risk of IFG, IGT and combined IFG and IGT. However, this risk was significant only in impaired glucose tolerance in vitamin D deficiency.