Clinical, Demographic, and Radiological Characteristics of Patients Demonstrating Antibodies Against Myelin Oligodendrocyte Glycoprotein

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dc.contributor.authorSumeyye Koc
dc.contributor.authorsedat şen
dc.contributor.authorYuksel Terzi
dc.contributor.authorFerah KIZILAY
dc.contributor.authorSerkan Demir
dc.contributor.authorDurdane Aksoy
dc.contributor.authorFatma Kurtulus
dc.contributor.authorNURAY BİLGE
dc.contributor.authorEgemen Idiman
dc.contributor.authorCihat Uzunköprü
dc.contributor.authorSERDAL GÜNGÖR
dc.contributor.authorVEDAT CILINGIR
dc.contributor.authorözlem ETHEMOĞLU
dc.contributor.authorCavit Boz
dc.contributor.authorHaluk Gumus
dc.contributor.authorahmet kasim kilic
dc.contributor.authorAYSIN KISABAY
dc.contributor.authorLevent Sinan Bir
dc.contributor.authorömer faruk turan
dc.contributor.authorAysun Soysal
dc.contributor.authorMesrure Koseoglu
dc.contributor.authorGÜLNUR TEKGÖL UZUNER
dc.contributor.authorHasan Bayındır
dc.contributor.authorsibel canbaz kabay
dc.contributor.authorMUSTAFA ÇAM
dc.contributor.authorVildan Yayla
dc.contributor.authorHüseyin TAN
dc.contributor.authorabdulcemal özcan
dc.contributor.authorOZLEM TASKAPILIOGLU
dc.contributor.authorMuammer KORKMAZ
dc.contributor.authorYusuf Tamam
dc.contributor.authorYılmaz İnanç
dc.contributor.authorHüsnü Efendi
dc.contributor.authordilcan kotan
dc.contributor.authorMehmet Fatih Yetkin
dc.contributor.authoradnan bilgic
dc.contributor.authorHikmet Sacmacı
dc.contributor.authorSerpil Demirci
dc.contributor.authorYahya Celik
dc.contributor.authorTURAN POYRAZ
dc.contributor.authorMurat Terzi
dc.date.accessioned2025-04-14T05:51:34Z
dc.date.available2025-04-14T05:51:34Z
dc.date.issued2024
dc.description.abstractBackground: Optic neuritis, myelitis, and neuromyelitis optica spectrum disorder (NMOSD) have been associated with antibodies against myelin oligodendrocyte glycoprotein-immunoglobulin G (anti-MOG-IgG). Furthermore, patients with radiological and demographic features atypical for multiple sclerosis (MS) with optic neuritis and myelitis also demonstrate antibodies against aquaporin-4 and anti-MOG-IgG. However, data on the diagnosis, treatment, follow-up, and prognosis in patients with anti-MOG-IgG are limited. Aims: To evaluate the clinical, radiological, and demographic characteristics of patients with anti-MOG-IgG. Study Design: Multicenter, retrospective, observational study. Methods: Patients with blood samples demonstrating anti-MOG-IgG that had been evaluated at the Neuroimmunology laboratory at Ondokuz Mayıs University’s Faculty of Medicine were included in the study. Results: Of the 104 patients with anti-MOG-IgG, 56.7% were women and 43.3% were men. Approximately 2.4% of the patients were diagnosed with MS, 15.8% with acute disseminated encephalomyelitis (ADEM), 39.4% with NMOSD, 31.3% with isolated optic neuritis, and 11.1% with isolated myelitis. Approximately 53.1% of patients with spinal involvement at clinical onset demonstrated a clinical course of NMOSD. Thereafter, 8.8% of these patients demonstrated a clinical course similar to MS and ADEM, and 28.1% demonstrated a clinical course of isolated myelitis. The response to acute attack treatment was lower and the disability was higher in patients aged > 40 years than patients aged < 40 years at clinical onset. Oligoclonal band was detected in 15.5% of the patients. Conclusion: For patients with NMOSD and without anti-NMO antibodies, the diagnosis is supported by the presence of anti-MOG-IgG. Furthermore, advanced age at clinical onset, Expanded Disability Status Scale (EDSS) score at clinical onset, spinal cord involvement, and number of attacks may be negative prognostic factors in patients with anti-MOG-IgG.
dc.identifier.DOI-ID10.4274/balkanmedj.galenos.2024.2024-1-97
dc.identifier.urihttp://hdl.handle.net/20.500.14701/54658
dc.language.isoİngilizce
dc.titleClinical, Demographic, and Radiological Characteristics of Patients Demonstrating Antibodies Against Myelin Oligodendrocyte Glycoprotein

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