The Effect of N-Acetylcysteine on the Neurofilament and Nerve Growth Factor Expression after Gentamicin Induced Cochlear Damage

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dc.contributor.authorSarsmaz, HY
dc.contributor.authorGürgen, SG
dc.contributor.authorSomdas, MA
dc.date.accessioned2024-07-18T11:54:17Z
dc.date.available2024-07-18T11:54:17Z
dc.description.abstractObjective: To investigate of the effectiveness of N-acetylcysteine (NAC) in preventing cochlear damage due to gentamicin by the means of expression of neuronal factors Metods: In our study, 36 female Spraguea Dawley rats were used. They were divided into 3 groups such as (saline), Gentamicin + Serum physiological (saline) and Gentamicin + NAC. After 15 days, the rats were sacrificed. Cochleae were removed and examined histopathologically. The immunoreactivity of neurofilament and neuronal growth factor primary antibodies was examined in the tissues taken. Results: Neuroflament immunoreactivity was quite significant in afferent and efferent nerve bundles in the saline group and Gentamicin + NAC group, whereas it was weak in the Gentamicin + serum physiological group. Also neuronal growth factor immunoreactivity was moderate in afferent and efferent nerve bundles in the saline group and Gentamicin + NAC group, it was negative at vestibular ganglia, and weak in afferent and efferent nerve fiber bundles in the Gentamicin + serum physiological group. Conclusion: It was shown immunohistochemically that ototoxicity caused by gentamicin was significantly reduced when the NAC combination was applied.
dc.identifier.issn2147-2092
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/6260
dc.language.isoTurkish
dc.publisherGAZI UNIV, FAC MED
dc.subjectCONTRAST-INDUCED NEPHROPATHY
dc.subjectINDUCED OTOTOXICITY
dc.subjectAMINOGLYCOSIDE OTOTOXICITY
dc.subjectINTRATYMPANIC GENTAMICIN
dc.subjectPLATINUM OTOTOXICITY
dc.subjectSODIUM THIOSULFATE
dc.subjectACETYL-CYSTEINE
dc.subjectHEARING-LOSS
dc.subjectCISPLATIN
dc.subjectPREVENTION
dc.titleThe Effect of N-Acetylcysteine on the Neurofilament and Nerve Growth Factor Expression after Gentamicin Induced Cochlear Damage
dc.typeArticle

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