Glycemic control, oxidative stress, and lipid profile in children with type 1 diabetes mellitus
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2004
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Abstract
Background In diabetes mellitus, persistence of hyperglycemia was reported to cause increased production of oxidative parameters including malondialdehyde (MDA). In the present study, the effect of glycemic control on oxidative stress and the lipid profile of pediatric type 1 diabetes mellitus (DM) patients were investigated. Methods Serum total cholesterol, HDL cholesterol, VLDL cholesterol, apolipoprotein A, apolipoprotein B, lipoprotein a, HbA 1c, and MDA levels were assessed in 96 children with type 1 DM. Study cases were evaluated in two groups in view of their mean HbA1c values, as metabolically well controlled (HbA1c ≤8%) and poorly controlled (HbA1c >8%) patients with DM. Fifty healthy children were included as normal controls. Results Total cholesterol, LDL cholesterol, apolipoprotein A, apolipoprotein B, and MDA levels of total diabetic patients were significantly (p<0.05) higher than those of the control group. Serum MDA levels and MDA/LDL cholesterol index were significantly increased in metabolically poorly controlled in relation to metabolically well-controlled DM patients and were similar in metabolically well-controlled DM patients with relation to control group and in metabolically poorly controlled patients with relation to control group. Conclusions In the present study, increased levels of MDA, MDA/LDL index, and dyslipoproteinemia showed that especially metabolically poorly controlled DM children are at high risk of atherosclerosis and vascular complications of DM and that there is a significant relationship between the lipid profile and oxidative stress. Thus, it may be appropriate to evaluate MDA in addition to routine laboratory assessments in evaluation of type 1 DM pediatric patients. © 2004 IMSS. Published by Elsevier Inc.
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Adolescent , Apolipoproteins A , Apolipoproteins B , Child , Child, Preschool , Cholesterol , Cholesterol, HDL , Cholesterol, LDL , Diabetes Mellitus, Type 1 , Female , Humans , Hyperglycemia , Lipid Metabolism , Lipids , Male , Oxidative Stress , 3,4 methylenedioxyamphetamine , apolipoprotein A , apolipoprotein B , cholesterol , glucose , hemoglobin A1c , high density lipoprotein cholesterol , lipid , lipoprotein A , very low density lipoprotein cholesterol , adolescent , article , association , child , childhood , cholesterol blood level , concentration (parameters) , controlled study , evaluation , female , glucose blood level , health status , human , insulin dependent diabetes mellitus , lipid analysis , major clinical study , male , metabolism , oxidative stress , pediatrics , statistical significance