Glycemic control, oxidative stress, and lipid profile in children with type 1 diabetes mellitus

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dc.contributor.authorErciyas F.
dc.contributor.authorTaneli F.
dc.contributor.authorArslan B.
dc.contributor.authorUslu Y.
dc.date.accessioned2024-07-22T08:24:38Z
dc.date.available2024-07-22T08:24:38Z
dc.date.issued2004
dc.description.abstractBackground In diabetes mellitus, persistence of hyperglycemia was reported to cause increased production of oxidative parameters including malondialdehyde (MDA). In the present study, the effect of glycemic control on oxidative stress and the lipid profile of pediatric type 1 diabetes mellitus (DM) patients were investigated. Methods Serum total cholesterol, HDL cholesterol, VLDL cholesterol, apolipoprotein A, apolipoprotein B, lipoprotein a, HbA 1c, and MDA levels were assessed in 96 children with type 1 DM. Study cases were evaluated in two groups in view of their mean HbA1c values, as metabolically well controlled (HbA1c ≤8%) and poorly controlled (HbA1c >8%) patients with DM. Fifty healthy children were included as normal controls. Results Total cholesterol, LDL cholesterol, apolipoprotein A, apolipoprotein B, and MDA levels of total diabetic patients were significantly (p<0.05) higher than those of the control group. Serum MDA levels and MDA/LDL cholesterol index were significantly increased in metabolically poorly controlled in relation to metabolically well-controlled DM patients and were similar in metabolically well-controlled DM patients with relation to control group and in metabolically poorly controlled patients with relation to control group. Conclusions In the present study, increased levels of MDA, MDA/LDL index, and dyslipoproteinemia showed that especially metabolically poorly controlled DM children are at high risk of atherosclerosis and vascular complications of DM and that there is a significant relationship between the lipid profile and oxidative stress. Thus, it may be appropriate to evaluate MDA in addition to routine laboratory assessments in evaluation of type 1 DM pediatric patients. © 2004 IMSS. Published by Elsevier Inc.
dc.identifier.DOI-ID10.1016/j.arcmed.2003.10.002
dc.identifier.issn01884409
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20066
dc.language.isoEnglish
dc.subjectAdolescent
dc.subjectApolipoproteins A
dc.subjectApolipoproteins B
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectCholesterol
dc.subjectCholesterol, HDL
dc.subjectCholesterol, LDL
dc.subjectDiabetes Mellitus, Type 1
dc.subjectFemale
dc.subjectHumans
dc.subjectHyperglycemia
dc.subjectLipid Metabolism
dc.subjectLipids
dc.subjectMale
dc.subjectOxidative Stress
dc.subject3,4 methylenedioxyamphetamine
dc.subjectapolipoprotein A
dc.subjectapolipoprotein B
dc.subjectcholesterol
dc.subjectglucose
dc.subjecthemoglobin A1c
dc.subjecthigh density lipoprotein cholesterol
dc.subjectlipid
dc.subjectlipoprotein A
dc.subjectvery low density lipoprotein cholesterol
dc.subjectadolescent
dc.subjectarticle
dc.subjectassociation
dc.subjectchild
dc.subjectchildhood
dc.subjectcholesterol blood level
dc.subjectconcentration (parameters)
dc.subjectcontrolled study
dc.subjectevaluation
dc.subjectfemale
dc.subjectglucose blood level
dc.subjecthealth status
dc.subjecthuman
dc.subjectinsulin dependent diabetes mellitus
dc.subjectlipid analysis
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmetabolism
dc.subjectoxidative stress
dc.subjectpediatrics
dc.subjectstatistical significance
dc.titleGlycemic control, oxidative stress, and lipid profile in children with type 1 diabetes mellitus
dc.typeArticle

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