English
| dc.contributor.author | Ozdemir, N | |
| dc.contributor.author | Toraman, A | |
| dc.contributor.author | Taneli, F | |
| dc.contributor.author | Yurekli, BS | |
| dc.contributor.author | Hekimsoy, Z | |
| dc.date.accessioned | 2024-07-18T11:57:43Z | |
| dc.date.available | 2024-07-18T11:57:43Z | |
| dc.description.abstract | SPRINGER INT PUBL AG | |
| dc.identifier.issn | 2520-8721 | |
| dc.identifier.uri | http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/7142 | |
| dc.language.iso | Article | |
| dc.publisher | 1109-3099 | |
| dc.subject | PurposeThe aim of our study is to evaluate whether serum Klotho/FGF-23 and apelin-13 can be used as new biomarkers for detection of development of nephropathy.MethodsIn this cross-sectional study, 88 type 2 diabetes mellitus (T2DM) patients and 38 healthy controls were included. The mean duration of T2DM was 11.4 & PLUSMN; 9.7 years. T2DM individuals were categorized into two groups as group 1 with e-GFR < 60 mL/min/1.73 m(2) and group 2 with e-GFR > 60 mL/min/1.73 m(2). They were also divided into two groups according to their 24 h urine albumin levels, classifying them as follows: normoalbuminuria if less than 30 mg/day and albuminuria if more than 30 mg/day.ResultsMean serum Klotho levels in the T2DM group were observed to be significantly higher than in the control group. Serum apelin-13 levels were observed to be significantly lower in the T2DM group compared to the control group (p < 0.001). In the diabetic group, apelin-13 levels were positively correlated with age, waist circumference, and albuminuria while they were negatively correlated with e-GFR. Apelin-13 levels were seen to be significantly higher in group 1 (p < 0.001).ConclusionApelin-13 levels were found to be significantly higher in individuals with diabetic nephropathy than in those without diabetic nephropathy. In the diabetic group, a significant relationship was detected between apelin-13 levels and albumin excretion. Based on these findings, we consider that serum Klotho and apelin-13 levels may have a protective effect on diabetic nephropathy and can additionally be used as a biomarker to predict diabetic nephropathy. | |
| dc.title | English | |
| dc.type | CHRONIC KIDNEY-DISEASE | |
| dc.type | KLOTHO | |
| dc.type | FIBROBLAST-GROWTH-FACTOR-23 | |
| dc.type | PROGRESSION | |
| dc.type | PREDICTOR | |
| dc.type | MORTALITY | |
| dc.type | INSULIN | |
| dc.type | FGF23 |