Effects of adrenaline pretreatment on the arrhythmias observed following ischemia and reperfusion in conscious and anesthetized rats
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2002
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Abstract
A short episode of ischemia induced by coronary artery occlusion can precondition the myocardium against arrhythmia. The factors that have the potential to protect the myocardium from subsequent ischemia and reperfusion are controversial. In this study, the pre-conditioning-like effects of adrenaline were investigated in both anesthetized and conscious rats. Adrenaline 0.1 and 0.5 mg/kg or saline was administered 10 min before coronary occlusion in conscious and anesthetized rats. The 0.5 mg/kg dose of adrenaline decreased the total duration of arrhythmia in both models. The incidence of ventricular fibrillation decreased and survival rate increased only in conscious rats administered 0.5 mg/kg adrenaline. As a result, it is suggested that exogenous administration of adrenaline before coronary ligation may precondition and protect the heart against arrhythmia.
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adrenalin , sodium chloride , anesthesia induction , animal experiment , animal model , article , consciousness , controlled study , coronary artery ligation , disease duration , dose response , drug effect , heart arrhythmia , heart infarction , heart infarction prevention , heart muscle , heart muscle ischemia , heart muscle reperfusion , heart protection , heart rate , heart ventricle fibrillation , incidence , male , mean arterial pressure , nonhuman , rat , survival rate