Effects of adrenaline pretreatment on the arrhythmias observed following ischemia and reperfusion in conscious and anesthetized rats

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dc.contributor.authorBozdogan O.
dc.contributor.authorEkerbicer N.
dc.contributor.authorSuveren E.
dc.contributor.authorBikmaz S.P.
dc.date.accessioned2024-07-22T08:25:09Z
dc.date.available2024-07-22T08:25:09Z
dc.date.issued2002
dc.description.abstractA short episode of ischemia induced by coronary artery occlusion can precondition the myocardium against arrhythmia. The factors that have the potential to protect the myocardium from subsequent ischemia and reperfusion are controversial. In this study, the pre-conditioning-like effects of adrenaline were investigated in both anesthetized and conscious rats. Adrenaline 0.1 and 0.5 mg/kg or saline was administered 10 min before coronary occlusion in conscious and anesthetized rats. The 0.5 mg/kg dose of adrenaline decreased the total duration of arrhythmia in both models. The incidence of ventricular fibrillation decreased and survival rate increased only in conscious rats administered 0.5 mg/kg adrenaline. As a result, it is suggested that exogenous administration of adrenaline before coronary ligation may precondition and protect the heart against arrhythmia.
dc.identifier.issn12056626
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20272
dc.language.isoEnglish
dc.subjectadrenalin
dc.subjectsodium chloride
dc.subjectanesthesia induction
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectarticle
dc.subjectconsciousness
dc.subjectcontrolled study
dc.subjectcoronary artery ligation
dc.subjectdisease duration
dc.subjectdose response
dc.subjectdrug effect
dc.subjectheart arrhythmia
dc.subjectheart infarction
dc.subjectheart infarction prevention
dc.subjectheart muscle
dc.subjectheart muscle ischemia
dc.subjectheart muscle reperfusion
dc.subjectheart protection
dc.subjectheart rate
dc.subjectheart ventricle fibrillation
dc.subjectincidence
dc.subjectmale
dc.subjectmean arterial pressure
dc.subjectnonhuman
dc.subjectrat
dc.subjectsurvival rate
dc.titleEffects of adrenaline pretreatment on the arrhythmias observed following ischemia and reperfusion in conscious and anesthetized rats
dc.typeArticle

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