Preparation of a 99mTc-labeled graft polymer and its in vitro and in vivo evaluation

Simple item page
dc.contributor.authorAvcıbaşı U.
dc.contributor.authorTürkyarar T.
dc.contributor.authorKaradağ A.
dc.contributor.authorBakan B.
dc.contributor.authorYavaşoğlu N.Ü.K.
dc.contributor.authorKuşat K.
dc.contributor.authorAkgöl S.
dc.contributor.authorGülcemal D.
dc.contributor.authorTekin V.
dc.contributor.authorMüftüler F.Z.B.
dc.contributor.authorTopal G.
dc.contributor.authorParlak Y.
dc.contributor.authorGümüşer F.G.
dc.date.accessioned2024-07-22T08:05:38Z
dc.date.available2024-07-22T08:05:38Z
dc.date.issued2021
dc.description.abstractThe aim of this study is the synthesis of a novel 99mTc-labeld graft polymer and the biological evaluation of its in vitro and in vivo properties. To this end, a L-proline-graft-poly(HEMA) was prepared and labeled with 99mTc. The radiochemical yield of approximately the 99mTc-labeled compound amounted to 97 ± 2.3%. The cytotoxicity test revealed no cytotoxic effect after a 24- and 48-h incubation. The results of the hemolysis test showed that hemolysis was non-toxic with an effect level of less than 2%. Subsequently, the biodistribution in healthy rats was determined. High accumulation of the polymer was observed in the pancreas, thyroid and prostate. © 2021, Akadémiai Kiadó, Budapest, Hungary.
dc.identifier.DOI-ID10.1007/s10967-021-07817-6
dc.identifier.issn02365731
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13204
dc.language.isoEnglish
dc.publisherSpringer Science and Business Media B.V.
dc.subjectpolymer
dc.subjecttechnetium 99m
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectchemical structure
dc.subjectcontrolled study
dc.subjectcytotoxicity
dc.subjectembryo
dc.subjectHEK293 cell line
dc.subjecthemolysis assay
dc.subjecthuman
dc.subjecthuman cell
dc.subjectin vitro study
dc.subjectin vivo study
dc.subjectincubation time
dc.subjectlipophilicity
dc.subjectmale
dc.subjectnonhuman
dc.subjectpancreas
dc.subjectprostate
dc.subjectradiolabeling
dc.subjectrat
dc.subjectsynthesis
dc.subjectthyroid gland
dc.subjectWistar rat
dc.titlePreparation of a 99mTc-labeled graft polymer and its in vitro and in vivo evaluation
dc.typeArticle

Files

Collections

Scopus Koleksiyonu