Glucose sensing employing fluorescent pH indicator: 4-[(p-N,N-dimethylamino)benzylidene]-2-phenyloxazole-5-one
| dc.contributor.author | Ertekin K. | |
| dc.contributor.author | Cinar S. | |
| dc.contributor.author | Aydemir T. | |
| dc.contributor.author | Alp S. | |
| dc.date.accessioned | 2025-04-10T11:17:18Z | |
| dc.date.available | 2025-04-10T11:17:18Z | |
| dc.date.issued | 2005 | |
| dc.description.abstract | The proton sensitive azlactone derivative; 4-[(p-N,N-dimethylamino) benzylidene]-2-phenyloxazole-5-one (DPO) exhibits high quantum yield, excellent photostability, and high molar absorptivity in a sol - gel matrix. In this work, two different DPO containing constructions were tested and evaluated as glucose sensors. In the first, both glucose oxidase (GOx) and azlactone derivative were incorporated into a single tetraethylorthosilicate (TEOS) based sol - gel phase. In the second, TEOS and 3-aminopropyltriethoxysilane (APTEOS) containing dye-doped sol - gel layer was covered with GOx entrapped sol - gel (the two-layer configuration). The monolayer configuration has the fastest response time (τ90 = 20 s) but suffers from leaching upon prolonged use. Response time and dynamic working range of the cross-linking agent containing two-layer configuration are 40 s and 0.1-15 mM glucose, respectively. The resulting glucose sensor was characterized by high sensitivity, low interference from acidogenic species, and a working lifetime of at least 90 days. © 2004 Elsevier Ltd. All rights reserved. | |
| dc.identifier.DOI-ID | 10.1016/j.dyepig.2004.11.001 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/52517 | |
| dc.title | Glucose sensing employing fluorescent pH indicator: 4-[(p-N,N-dimethylamino)benzylidene]-2-phenyloxazole-5-one | |
| dc.type | Article |