The lethality, histological, haematological and biochemical alterations in mice envenomated with Aegaeobuthus nigrocinctus venom
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2021
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Abstract
There is currently no data regarding the toxicity or the in vivo effects of the venom the Aegaeobuthus nigrocinctus species, since it has not been studied thus far according to the best of our knowledge. In the present study, and for the first time, the median lethal dose, the in vivo toxic effects, the histological changes in some of the vital organs were all determined as well as an assessment was made of the histological, biochemical and haematological changes which were caused by the venom injected in mice. The median lethal dose (LD50) of the scorpion venom for mice was found to be 0.38 mg/kg in terms of body weight. The results of the study show that the A. nigrocintus is a potentially lethal scorpion. The evidence related to the venom indicated that it could cause tissue injury in some vital organs. In conclusion, this scorpion venom could cause significant medical complications, and may lead to death, regarding at-risk patients. Therefore, health professionals should be aware of the various scorpion species in their regions and should follow current medical approaches concerning scorpion envenomation. © 2021 Elsevier Ltd
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Animals , Humans , Lethal Dose 50 , Mice , Scorpion Stings , Scorpion Venoms , Scorpions , alanine aminotransferase , albumin , aspartate aminotransferase , biological marker , creatinine , glucose , hemoglobin , protein , urea , scorpion venom , aegaeobuthus nigrocinctus venom , anesthesia , animal experiment , animal model , Article , basophil , bioassay , biochemical analysis , blood sampling , body weight , brain tissue , coma , death , dyspnea , envenomation , erythrocyte , female , health practitioner , heart tissue , hematocrit , hematology , histological assay , histology , histopathology , hyperactivity , hyperemia , hypersalivation , in vivo study , intestine tissue , jumping , kidney tissue , lacrimation , lethal dose , lethality , leukocyte , liver cell , liver tissue , lung parenchyma , lymph follicle , lymphocyte , lymphoid hyperplasia , male , mean corpuscular hemoglobin , mean corpuscular hemoglobin concentration , mean corpuscular volume , megakaryocyte , monocyte , mouse , muscle cell , neutrophil , nonhuman , pancreas tissue , platelet count , ptosis (eyelid) , reflex , scorpion , spleen tissue , tachypnea , tissue injury , tissues , toxicity , ultraviolet radiation , urea nitrogen blood level , walking , animal , human , LD50 , scorpion , scorpion sting