The lethality, histological, haematological and biochemical alterations in mice envenomated with Aegaeobuthus nigrocinctus venom

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dc.contributor.authorBakır F.
dc.contributor.authorOzkan O.
dc.contributor.authorAlcigir M.E.
dc.contributor.authorYagmur E.A.
dc.date.accessioned2024-07-22T08:05:45Z
dc.date.available2024-07-22T08:05:45Z
dc.date.issued2021
dc.description.abstractThere is currently no data regarding the toxicity or the in vivo effects of the venom the Aegaeobuthus nigrocinctus species, since it has not been studied thus far according to the best of our knowledge. In the present study, and for the first time, the median lethal dose, the in vivo toxic effects, the histological changes in some of the vital organs were all determined as well as an assessment was made of the histological, biochemical and haematological changes which were caused by the venom injected in mice. The median lethal dose (LD50) of the scorpion venom for mice was found to be 0.38 mg/kg in terms of body weight. The results of the study show that the A. nigrocintus is a potentially lethal scorpion. The evidence related to the venom indicated that it could cause tissue injury in some vital organs. In conclusion, this scorpion venom could cause significant medical complications, and may lead to death, regarding at-risk patients. Therefore, health professionals should be aware of the various scorpion species in their regions and should follow current medical approaches concerning scorpion envenomation. © 2021 Elsevier Ltd
dc.identifier.DOI-ID10.1016/j.toxicon.2021.07.010
dc.identifier.issn00410101
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13250
dc.language.isoEnglish
dc.publisherElsevier Ltd
dc.subjectAnimals
dc.subjectHumans
dc.subjectLethal Dose 50
dc.subjectMice
dc.subjectScorpion Stings
dc.subjectScorpion Venoms
dc.subjectScorpions
dc.subjectalanine aminotransferase
dc.subjectalbumin
dc.subjectaspartate aminotransferase
dc.subjectbiological marker
dc.subjectcreatinine
dc.subjectglucose
dc.subjecthemoglobin
dc.subjectprotein
dc.subjecturea
dc.subjectscorpion venom
dc.subjectaegaeobuthus nigrocinctus venom
dc.subjectanesthesia
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectArticle
dc.subjectbasophil
dc.subjectbioassay
dc.subjectbiochemical analysis
dc.subjectblood sampling
dc.subjectbody weight
dc.subjectbrain tissue
dc.subjectcoma
dc.subjectdeath
dc.subjectdyspnea
dc.subjectenvenomation
dc.subjecterythrocyte
dc.subjectfemale
dc.subjecthealth practitioner
dc.subjectheart tissue
dc.subjecthematocrit
dc.subjecthematology
dc.subjecthistological assay
dc.subjecthistology
dc.subjecthistopathology
dc.subjecthyperactivity
dc.subjecthyperemia
dc.subjecthypersalivation
dc.subjectin vivo study
dc.subjectintestine tissue
dc.subjectjumping
dc.subjectkidney tissue
dc.subjectlacrimation
dc.subjectlethal dose
dc.subjectlethality
dc.subjectleukocyte
dc.subjectliver cell
dc.subjectliver tissue
dc.subjectlung parenchyma
dc.subjectlymph follicle
dc.subjectlymphocyte
dc.subjectlymphoid hyperplasia
dc.subjectmale
dc.subjectmean corpuscular hemoglobin
dc.subjectmean corpuscular hemoglobin concentration
dc.subjectmean corpuscular volume
dc.subjectmegakaryocyte
dc.subjectmonocyte
dc.subjectmouse
dc.subjectmuscle cell
dc.subjectneutrophil
dc.subjectnonhuman
dc.subjectpancreas tissue
dc.subjectplatelet count
dc.subjectptosis (eyelid)
dc.subjectreflex
dc.subjectscorpion
dc.subjectspleen tissue
dc.subjecttachypnea
dc.subjecttissue injury
dc.subjecttissues
dc.subjecttoxicity
dc.subjectultraviolet radiation
dc.subjecturea nitrogen blood level
dc.subjectwalking
dc.subjectanimal
dc.subjecthuman
dc.subjectLD50
dc.subjectscorpion
dc.subjectscorpion sting
dc.titleThe lethality, histological, haematological and biochemical alterations in mice envenomated with Aegaeobuthus nigrocinctus venom
dc.typeArticle

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