Can maternal urinary and serum carbohydrate antigen 19-9 concentrations be utilized in the diagnosis of fetal hydronephrosis?
| dc.contributor.author | Akbas, M | |
| dc.contributor.author | Koyuncu, FM | |
| dc.contributor.author | Ülkümen, BA | |
| dc.contributor.author | Taneli, F | |
| dc.contributor.author | Özdemir, H | |
| dc.date.accessioned | 2024-07-18T11:49:16Z | |
| dc.date.available | 2024-07-18T11:49:16Z | |
| dc.description.abstract | Objective: Fetal hydronephrosis (FH) is the most common fetal renal pathology encountered in daily obstetric practice. Urinary and scrum carbohydrate antigen 19-9 (CA 19-9) concentrations are elevated in obstructive renal pathologies. Our aim was to assess maternal urinary and serum CA 19-9 concentrations in pregnancies with FH and compare results with controls. Material and Methods: Twenty pregnancies with severe FH, 20 pregnancies with mild-moderate FH, and 20 healthy singleton pregnancies were included in this descriptive, case-control study. The diagnosis and classification of FH was based on the anterioposterior diameter of fetal renal pelvis. Maternal urinary and serum CA 19-9 concentrations were measured and compared between groups. Results: Severe FH cases had significantly higher maternal urinary CA 19-9 concentrations compared to controls (median: 75 vs 24 U/mL; respectively; p= 0.014). Concentrations of CA 19-9 did not differ between the mild-moderate FH group and control group. No statistically significant difference was found between the groups with respect to maternal serum CA 19-9 concentrations. Conclusion: Our results show that maternal urinary CA 19-9 concentration is significantly higher in pregnancies with severe FH. However, no difference was detected in serum CA 19-9 concentrations between pregnancies with severe FH, mild-moderate FH and controls. If the mechanisms of transplacental passage and maternal urinary excretion are clarified, maternal urinary CA 19-9 may be a potential marker for indicating fetal kidney damage. | |
| dc.identifier.issn | 1309-0399 | |
| dc.identifier.other | 1309-0380 | |
| dc.identifier.uri | http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/3892 | |
| dc.language.iso | English | |
| dc.publisher | GALENOS YAYINCILIK | |
| dc.subject | TUMOR-MARKERS | |
| dc.subject | CA-19-9 | |
| dc.subject | MANAGEMENT | |
| dc.subject | CA-125 | |
| dc.subject | CA-50 | |
| dc.title | Can maternal urinary and serum carbohydrate antigen 19-9 concentrations be utilized in the diagnosis of fetal hydronephrosis? | |
| dc.type | Article |