An anxiolytic drug buspirone ameliorates hyperglycemia and endothelial dysfunction in type 2 diabetic rat model; [Anksiyolitik bir ilaç olan buspiron tip 2 diyabet sıçan modelinde hiperglisemi ve endotelyal disfonksiyonu düzeltiyor]
| dc.contributor.author | Çavuşoğlu T.G. | |
| dc.contributor.author | Darıverenli E. | |
| dc.contributor.author | Vural K. | |
| dc.contributor.author | Ekerbicer N. | |
| dc.contributor.author | Ulman C. | |
| dc.contributor.author | Ölmez E. | |
| dc.contributor.author | Uysal N. | |
| dc.date.accessioned | 2025-04-10T11:06:20Z | |
| dc.date.available | 2025-04-10T11:06:20Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | Objectives: Type 2 diabetes is a common metabolic disease and anxiety disorders are very common among diabetics. Buspirone is used in the treatment of anxiety, also having blood glucose-lowering effects. The aim of the study was to investigate the effects of buspirone on the glucose and lipid metabolism as well as vascular function in type 2 diabetic rats. Methods: A type 2-diabetic model was induced through a high-fat diet for eight weeks followed by the administration of low-dose streptozotocin (35 mg/kg, intraperitoneal) in rats. Buspirone was given at two different doses (1.5 mg/kg/d and 5 mg/kg/d) and combined with metformin (300 mg/kg/d). The fasting glucose and insulin levels, lipid profile were analyzed, and vascular response measured from the thoracic aorta was also evaluated. Results: Both doses of buspirone caused a significant improvement in fasting blood glucose levels. In particular, the buspirone treatment, combined with metformin, improved endothelial dysfunction and was found to be correlated with decreased nitrate/nitrite levels. Conclusions: Buspirone may be effective in the treatment of type 2 diabetes, either alone or in combination with other treatments, particularly in terms of endothelial dysfunction, inflammation and impaired blood glucose, and insulin levels. © 2020 De Gruyter. All rights reserved. | |
| dc.identifier.DOI-ID | 10.1515/TJB-2019-0224 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/46640 | |
| dc.publisher | De Gruyter Open Ltd | |
| dc.title | An anxiolytic drug buspirone ameliorates hyperglycemia and endothelial dysfunction in type 2 diabetic rat model; [Anksiyolitik bir ilaç olan buspiron tip 2 diyabet sıçan modelinde hiperglisemi ve endotelyal disfonksiyonu düzeltiyor] | |
| dc.type | Article |