COMPARISON OF FETUIN A LEVELS BEFORE AND AFTER IMMUNOTHERAPY IN PATIENTS WITH ALLERGIC RHINITIS
No Thumbnail Available
Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Introduction: Role of Fetuin-A, a serum glycoprotein, in various diseases has been reported in different studies. There is no available study yet about Fetuin A in allergic diseases. We aimed to determine the role of Fetuin-A in Allergic Rhinitis (AR). Material and Methods: 30 patients aged over 18 and 30 healthy volunteers due to AR were enrolled in the study. Initial and sixth month serum level and nasal lavage Fetuin-A levels as well as nasal symptom scores were compared. Results: Mean Serum Fetuin-A level of patients with AR was found to be 1010.44 ± 679.84mg/L, while mean nasal Fetuin A level was found 946.52 ± 127.123mg/L. The decrease in serum fetuin A (P=0.046) and nasal Fetuin A (P<0.001) levels and nasal symptoms encountered after treatment were statistically significant. Serum Fetuin A increase was determined as a risk factor for AR development in analysis results (RR:1.009, P<0.001).Conclusion:Determination of the changes that were considered as statistically significant in serum and nasal Fetuin A levels led us to the conclusition that Fetuin-A may be a marker in AR in this study aiming to examine the systemic and local levels of Fetuin A in patients with AR. As a result of the analysis, the increase in serum fetuin A level was found to be a risk factor for AR development (RR: 1.009, P <0.001).