The effects of mechanical ventilation on heart rate variability and complexity in mice

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dc.contributor.authorKazdağli H.
dc.contributor.authorÖzel H.F.
dc.contributor.authorÖzbek M.
dc.date.accessioned2024-07-22T08:03:07Z
dc.date.available2024-07-22T08:03:07Z
dc.date.issued2023
dc.description.abstractIn a variety of diseases, altered respiratory modulation is often as an early sign of autonomic dysfunction. Therefore, understanding and evaluating the effects of mechanical ventilation on the autonomic nervous system is vital. The effects of mechanical ventilation on autonomic balance have been assessed by heart rate variability (HRV) using frequency domain and non-linear analysis including fractal complexity and entropy analysis in anesthetized mice. BALB/c mice (n=48) were divided into two groups: Spontaneous breathing and mechanical ventilation. The electrocardiograms were recorded. Four different types of analysis were employed: i. frequency domain analysis, ii. Poincaré plots, iii. Detrended Fluctuation Analysis (DFA) and iv. Entropy analysis. An unpaired t-test was used for statistical analysis. In a ventilated group, very low frequency (VLF) and low frequency (LF) parameters were not changed, whereas the high frequency parameter was decreased compared to spontaneous breathing mice. DFAa1 was significantly increased due to mechanical ventilation but DFAa2 was unchanged. In Poincaré plots analysis, standard deviation 2 (SD2) / standard deviation 1 (SD1) ratio was increased, however, SD1 and SD2 were not significantly affected. Also, Approximate Entropy and Sample Entropy remained unchanged. HF parameter, DFAa1, and SD2/SD1 were affected by mechanical ventilation. Decreased HF and increased DFAa1, further support the notion that HRV is dominated by respiratory sinus arrhythmia at high frequencies, this may be due to decreased vagal tone caused by mechanical ventilation. This novel results of HRV analysis are important considering increased usage of HRV techniques day by day in animal models and other medical practices. © 2023 H Kazdağli, HF Ozel, MA Özbek. All Rights Reserved.
dc.identifier.DOI-ID10.12681/jhvms.32121
dc.identifier.issn17922720
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/12139
dc.language.isoEnglish
dc.publisherHellenic Veterinary Medical Society
dc.rightsAll Open Access; Hybrid Gold Open Access
dc.subjectfentanyl
dc.subjectpentobarbital
dc.subjectanesthesia
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectArticle
dc.subjectartificial ventilation
dc.subjectautonomic dysfunction
dc.subjectautonomic nervous system
dc.subjectbreathing pattern
dc.subjectbreathing rate
dc.subjectdetrended fluctuation analysis
dc.subjectelectrocardiogram
dc.subjectelectrocardiography
dc.subjectentropy
dc.subjectgene frequency
dc.subjectheart rate
dc.subjectheart rate variability
dc.subjecthypothermia
dc.subjectmale
dc.subjectmedical practice
dc.subjectmouse
dc.subjectnonhuman
dc.subjectpoincare plot
dc.subjectpower spectrum
dc.subjectprobability
dc.subjectQRS interval
dc.subjectquantitative analysis
dc.subjectR wave
dc.subjectrespiration control
dc.subjectrespiratory sinus arrhythmia
dc.subjectRR interval
dc.subjecttime series analysis
dc.subjecttracheostomy
dc.subjectultra low frequency
dc.subjectvery high frequency
dc.titleThe effects of mechanical ventilation on heart rate variability and complexity in mice
dc.typeArticle

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