The increase of neuropathic symptoms in diabetic patients is related with osteopenia
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Date
2021
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Abstract
Purpose: To investigate the relationship between the intensity of neuropathic pain and the severity of osteopenia in type 2 diabetic patients with painful diabetic peripheral neuropathy (painful DPN). Methods: In 220 patients with type 2 diabetes included in the screening, the presence of neuropathic pain was evaluated using the Douleur Neuropathique 4 Questions (DN4) scoring system. One hundred forty-five patients with painful DPN were identified and included in the study. Socio-demographic and laboratory evaluations were made and bone mineral density (BMD) of these patients was evaluated by the dual-energy x-ray absorptiometry (DEXA) method. Results: There was a significant correlation between the neuropathic pain score and the total T scores of the lumbar spine and femur in patients with painful DPN. According to the regression analysis (standard coefficients), the DN4 score (0.498); the level of vitamin D (− 0.246) and the female sex (0.236) for the lumbar spine region; age (0.387); DN4 score (0.261); and vitamin D level (− 0.155) for the femur region were independently influencing factors on the development of osteoporosis. When osteoporosis (T score ≤ − 2.5) of the lumbar spine was analyzed by binary logistic regression, the risk of osteoporosis in women was 4.4 times higher, and the risk increased with increasing DN4 score. Conclusion: The increase of neuropathic symptoms in patients with DPN is an effective and important factor in the development of diabetic osteopenia. © 2020, Fondazione Società Italiana di Neurologia.
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Absorptiometry, Photon , Bone Density , Bone Diseases, Metabolic , Diabetes Mellitus, Type 2 , Diabetic Neuropathies , Female , Humans , albumin , analgesic agent , bisphosphonic acid derivative , calcium , vitamin D , adult , Article , bone density , cross-sectional study , diabetic neuropathy , diabetic patient , douleur neuropathique 4 questions , dual energy X ray absorptiometry , female , femur , human , human tissue , lumbar spine , major clinical study , male , middle aged , neuropathic pain , non insulin dependent diabetes mellitus , osteopenia , osteoporosis , receiver operating characteristic , scoring system , complication , diabetic neuropathy , diagnostic imaging , metabolic bone disease , non insulin dependent diabetes mellitus , photon absorptiometry