The increase of neuropathic symptoms in diabetic patients is related with osteopenia

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dc.contributor.authorBörekci E.
dc.contributor.authorKara A.
dc.contributor.authorKılıç M.
dc.contributor.authorTanık N.
dc.contributor.authorOzan Z.T.
dc.contributor.authorYıldırım T.
dc.contributor.authorAral Y.
dc.date.accessioned2024-07-22T08:06:01Z
dc.date.available2024-07-22T08:06:01Z
dc.date.issued2021
dc.description.abstractPurpose: To investigate the relationship between the intensity of neuropathic pain and the severity of osteopenia in type 2 diabetic patients with painful diabetic peripheral neuropathy (painful DPN). Methods: In 220 patients with type 2 diabetes included in the screening, the presence of neuropathic pain was evaluated using the Douleur Neuropathique 4 Questions (DN4) scoring system. One hundred forty-five patients with painful DPN were identified and included in the study. Socio-demographic and laboratory evaluations were made and bone mineral density (BMD) of these patients was evaluated by the dual-energy x-ray absorptiometry (DEXA) method. Results: There was a significant correlation between the neuropathic pain score and the total T scores of the lumbar spine and femur in patients with painful DPN. According to the regression analysis (standard coefficients), the DN4 score (0.498); the level of vitamin D (− 0.246) and the female sex (0.236) for the lumbar spine region; age (0.387); DN4 score (0.261); and vitamin D level (− 0.155) for the femur region were independently influencing factors on the development of osteoporosis. When osteoporosis (T score ≤ − 2.5) of the lumbar spine was analyzed by binary logistic regression, the risk of osteoporosis in women was 4.4 times higher, and the risk increased with increasing DN4 score. Conclusion: The increase of neuropathic symptoms in patients with DPN is an effective and important factor in the development of diabetic osteopenia. © 2020, Fondazione Società Italiana di Neurologia.
dc.identifier.DOI-ID10.1007/s10072-020-04915-3
dc.identifier.issn15901874
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13350
dc.language.isoEnglish
dc.publisherSpringer-Verlag Italia s.r.l.
dc.subjectAbsorptiometry, Photon
dc.subjectBone Density
dc.subjectBone Diseases, Metabolic
dc.subjectDiabetes Mellitus, Type 2
dc.subjectDiabetic Neuropathies
dc.subjectFemale
dc.subjectHumans
dc.subjectalbumin
dc.subjectanalgesic agent
dc.subjectbisphosphonic acid derivative
dc.subjectcalcium
dc.subjectvitamin D
dc.subjectadult
dc.subjectArticle
dc.subjectbone density
dc.subjectcross-sectional study
dc.subjectdiabetic neuropathy
dc.subjectdiabetic patient
dc.subjectdouleur neuropathique 4 questions
dc.subjectdual energy X ray absorptiometry
dc.subjectfemale
dc.subjectfemur
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectlumbar spine
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmiddle aged
dc.subjectneuropathic pain
dc.subjectnon insulin dependent diabetes mellitus
dc.subjectosteopenia
dc.subjectosteoporosis
dc.subjectreceiver operating characteristic
dc.subjectscoring system
dc.subjectcomplication
dc.subjectdiabetic neuropathy
dc.subjectdiagnostic imaging
dc.subjectmetabolic bone disease
dc.subjectnon insulin dependent diabetes mellitus
dc.subjectphoton absorptiometry
dc.titleThe increase of neuropathic symptoms in diabetic patients is related with osteopenia
dc.typeArticle

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