Effect of chemotherapy on pulmonary epithelial permeability in lung cancer

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dc.contributor.authorSayit, E
dc.contributor.authorAktogu, S
dc.contributor.authorErtay, T
dc.contributor.authorÇapa, G
dc.contributor.authorErkmen, G
dc.contributor.authorÖzbilek, E
dc.contributor.authorBüyüksirin, M
dc.contributor.authorDurak, H
dc.date.accessioned2024-07-18T12:03:36Z
dc.date.available2024-07-18T12:03:36Z
dc.description.abstractThe aim of this study is to investigate the effect of one course chemotherapy on the pulmonary epithelial permeability. Eighteen patients (18 male; mean age: 59 +/- 10 years) with lung cancer (11 non-small cell, 7 small cell) inhaled 40 mCi (1,480 MBq) Tc-99m-diethylenetriaminepentaacetic acid (DTPA). Thirty images of 1-min duration were acquired from posterior projection. The first 7 min of the decay corrected time activity curves were used to calculate lung clearance half time. Clearance half times of Tc-99m-DTPA from the peripheral regions of the lungs were 42 +/- 19 min before and 56 +/- 34 min after chemotherapy (p = 0.009); from the central regions, clearance half-times were 112 +/- 94 min before and 160 +/- 125 min after chemotherapy (P = 0.005). This decrease in clearance rate might be related to decreasing mucociliary clearance rate due to the toxic effect of the chemotherapy regimen on cilia movement and/or mucus structure. Tc-99m DTPA radioaerosol study can be used to monitor the toxic effects of chemotherapy on the pulmonary epithelium and possibly on mucociliary function. NUCL MED BIOL 27;6:581-585, 2000. (C) 2000 Elsevier Science Inc. All rights reserved.
dc.identifier.issn0969-8051
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/9247
dc.language.isoEnglish
dc.publisherELSEVIER SCIENCE INC
dc.subjectTRACHEOBRONCHIAL CLEARANCE
dc.subjectMUCOCILIARY CLEARANCE
dc.subjectTOXICITY
dc.subjectBLEOMYCIN
dc.subjectDISEASE
dc.subjectAGENTS
dc.titleEffect of chemotherapy on pulmonary epithelial permeability in lung cancer
dc.typeArticle; Proceedings Paper

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