Reproducibility of the 1998 World Health Organization/International Society of Urologic Pathology classification of papillary urothelial neoplasms of the urinary bladder

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dc.contributor.authorYorukoglu K.
dc.contributor.authorTuna B.
dc.contributor.authorDikicioglu E.
dc.contributor.authorDuzcan E.
dc.contributor.authorIsisag A.
dc.contributor.authorSen S.
dc.contributor.authorMungan U.
dc.contributor.authorKirkali Z.
dc.date.accessioned2025-04-10T11:17:47Z
dc.date.available2025-04-10T11:17:47Z
dc.date.issued2003
dc.description.abstractObjectives: This study assessed the diagnostic agreement and intra- and inter-observer reproducibility of the World Health Organization/International Society of Urologic Pathology Consensus Classification of Urothelial Neoplasms (1998 WHO/ISUP classification) and the 1973 WHO classification. Methods: A teaching set with 5 slides of each papillary neoplasm of low malignant potential, low-grade papillary carcinoma, high-grade papillary carcinoma, and a guideline, as well as a study set of 30 slides containing ten cases of each category, were sent to participants. Six pathologists expert in urological pathology reviewed the 30 slides of non-invasive papillary urothelial tumors in the study set. Diagnostic accuracy and reproducibility were evaluated using intra- and inter-rater techniques (kappa statistic). Results: A moderate to substantial intra- and inter-observer reproducibility was achieved for both the 1998 WHO/ISUP and 1973 WHO classification. The results of the two classification systems were not different statistically (P>0.05). Reproducibility was lower in low-grade tumors for both classifications. Conclusions: The new proposed classification system for non-invasive urothelial neoplasms does not increase the reproducibility. There is still a need for uniformity in grading in order to compare the different studies and therapies and to provide more accurate information for management.
dc.identifier.DOI-ID10.1007/s00428-003-0905-0
dc.identifier.urihttp://hdl.handle.net/20.500.14701/52936
dc.titleReproducibility of the 1998 World Health Organization/International Society of Urologic Pathology classification of papillary urothelial neoplasms of the urinary bladder
dc.typeReview

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