Association Between Interleukin-6 and Head and Neck Squamous Cell Carcinoma: A Systematic Review

Simple item page
dc.contributor.authorUz, U
dc.contributor.authorEskiizmir, G
dc.date.accessioned2024-07-18T12:00:10Z
dc.date.available2024-07-18T12:00:10Z
dc.description.abstractInterleukin-6 (IL-6) is a proinflammatory cytokine which plays an important role in several regulatory mechanisms of cancer. Moreover, experimental and clinical studies have reported that IL-6 targeted therapies might provide significant benefits for cancer treatment. The purpose of this systematic review is to evaluate IL-6 activity in patients with head and neck squamous cell carcinoma (HNSCC). A systematic review of the association between serum, saliva and tumor IL-6 and HNSCC was developed on PubMed/Medline in the publication range from January 1995 to January 2019. Our literature analysis demonstrated that overexpression and elevated serum and/or saliva 1L-6 concentrations in patients with HNSCC are related to poor survival and oncological outcomes. Although there is a correlation between IL-6 concentrations and tumorigenicity, it is noteworthy that IL-6 targeted therapies are generally performed in vitro and in experimental studies.Therefore, prospective, randomized clinical trials are required that focus on IL-6 targeted therapies for the treatment of HNSCC.
dc.identifier.issn1976-8710
dc.identifier.other2005-0720
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/7519
dc.language.isoEnglish
dc.publisherKOREAN SOC OTORHINOLARYNGOL
dc.subjectNF-KAPPA-B
dc.subjectCANCER CACHEXIA UPDATE
dc.subjectNECROSIS-FACTOR-ALPHA
dc.subjectORAL-CANCER
dc.subjectSALIVARY INTERLEUKIN-6
dc.subjectCYTOKINE SECRETION
dc.subjectSERUM-LEVELS
dc.subjectTNF-ALPHA
dc.subjectIL-6
dc.subjectBIOMARKERS
dc.titleAssociation Between Interleukin-6 and Head and Neck Squamous Cell Carcinoma: A Systematic Review
dc.typeReview

Files

Collections

Web of Science Koleksiyonu