Musculoskeletal manifestations in children with Behcet's syndrome: data from the AIDA Network Behcet's Syndrome Registry

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dc.contributor.authorGaggiano, C
dc.contributor.authorMaselli, A
dc.contributor.authorSfikakis, PP
dc.contributor.authorLaskari, K
dc.contributor.authorRagab, G
dc.contributor.authorHegazy, MT
dc.contributor.authorLaymouna, AH
dc.contributor.authorLopalco, G
dc.contributor.authorAlmaghlouth, IA
dc.contributor.authorAsfina, KN
dc.contributor.authorAlahmed, O
dc.contributor.authorMayrink, HAG
dc.contributor.authorAntonelli, IPD
dc.contributor.authorCattalini, M
dc.contributor.authorPiga, M
dc.contributor.authorSota, J
dc.contributor.authorGentileschi, S
dc.contributor.authorMaggio, MC
dc.contributor.authorOpris-Belinski, D
dc.contributor.authorHatemi, G
dc.contributor.authorInsalaco, A
dc.contributor.authorOlivieri, AN
dc.contributor.authorTufan, A
dc.contributor.authorKaradeniz, H
dc.contributor.authorKardas, RC
dc.contributor.authorLa Torre, F
dc.contributor.authorCardinale, F
dc.contributor.authorMarino, A
dc.contributor.authorGuerriero, S
dc.contributor.authorRuscitti, P
dc.contributor.authorTarsia, M
dc.contributor.authorVitale, A
dc.contributor.authorCaggiano, V
dc.contributor.authorTelesca, S
dc.contributor.authorIannone, F
dc.contributor.authorParretti, V
dc.contributor.authorFrassi, M
dc.contributor.authorAragona, E
dc.contributor.authorCiccia, F
dc.contributor.authorWiesik-Szewczyk, E
dc.contributor.authorIonescu, R
dc.contributor.authorSahin, A
dc.contributor.authorAkkoç, N
dc.contributor.authorHinojosa-Azaola, A
dc.contributor.authorTharwat, S
dc.contributor.authorHernández-Rodríguez, J
dc.contributor.authorEspinosa, G
dc.contributor.authorConti, G
dc.contributor.authorDel Giudice, E
dc.contributor.authorGovoni, M
dc.contributor.authorEmmi, G
dc.contributor.authorFabiani, C
dc.contributor.authorBalistreri, A
dc.contributor.authorFrediani, B
dc.contributor.authorRigante, D
dc.contributor.authorCantarini, L
dc.date.accessioned2024-07-18T12:08:44Z
dc.date.available2024-07-18T12:08:44Z
dc.description.abstractThis study aims to describe musculoskeletal manifestations (MSM) in children with Behcet's syndrome (BS), their association with other disease manifestations, response to therapy, and long-term prognosis. Data were retrieved from the AIDA Network Behcet's Syndrome Registry. Out of a total of 141 patients with juvenile BS, 37 had MSM at disease onset (26.2%). The median age at onset was 10.0 years (IQR 7.7). The median follow-up duration was 21.8 years (IQR 23.3). Recurrent oral (100%) and genital ulcers (67.6%) and pseudofolliculitis (56.8%) were the most common symptoms associated with MSM. At disease onset, 31 subjects had arthritis (83.8%), 33 arthralgia (89.2%), and 14 myalgia (37.8%). Arthritis was monoarticular in 9/31 cases (29%), oligoarticular in 10 (32.3%), polyarticular in 5 (16.1%), axial in 7 (22.6%). Over time, arthritis became chronic-recurrent in 67.7% of cases and 7/31 patients had joint erosions (22.6%). The median Behcet's Syndrome Overall Damage Index was 0 (range 0-4). Colchicine was inefficacious for MSM in 4/14 cases (28.6%), independently from the type of MSM (p = 0.46) or the concomitant therapy (p = 0.30 for cDMARDs, p = 1.00 for glucocorticoids); cDMARDs and bDMARDs were inefficacious for MSM in 6/19 (31.4%) and 5/12 (41.7%) cases. The presence of myalgia was associated with bDMARDs inefficacy (p = 0.014). To conclude, MSM in children with BS are frequently associated with recurrent ulcers and pseudofolliculitis. Arthritis is mostly mono- or oligoarticular, but sacroiliitis is not unusual. Prognosis of this subset of BS is overall favorable, though the presence of myalgia negatively affects response to biologic therapies. ClinicalTrials.gov Identifier: NCT05200715 (registered on December 18, 2021).
dc.identifier.issn1828-0447
dc.identifier.other1970-9366
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11055
dc.language.isoEnglish
dc.publisherSPRINGER-VERLAG ITALIA SRL
dc.subjectCOMPUTED-TOMOGRAPHY
dc.subjectDISEASE
dc.subjectSACROILIITIS
dc.subjectARTHRITIS
dc.subjectCRITERIA
dc.subjectACNE
dc.titleMusculoskeletal manifestations in children with Behcet's syndrome: data from the AIDA Network Behcet's Syndrome Registry
dc.typeArticle

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